Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510080, China.
J Orthop Surg Res. 2023 Jan 2;18(1):1. doi: 10.1186/s13018-022-03481-y.
Osteoporosis is a major public health problem. Dietary inflammatory preference and body mass index (BMI) are emerging factors that tends to affect bone health. There is limited evidence regarding the joint influence of BMI and dietary status on the bone health. This study aimed to investigate the relationship between dietary inflammatory index (DII) and bone health among adults under different levels of BMI utilizing the National Health and Nutrition Examination Survey (NHANES).
Data were collected from 2005-2010, 2013-2014 to 2017-2018 in NHANES. In total, 10,521 participants who aged ≥ 20 years and had complete data for dietary intake interview, bone mineral density (BMD) and bone mineral content (BMC) were included. DII was performed to evaluate the dietary inflammatory potential based on dietary intake interview. We evaluated bone health by femoral neck BMD and BMC measured by dual energy X-ray absorptiometry. Weighted multivariable linear regression and BMI-stratified subgroup analysis were performed.
The average DII score for 10,521 participants was 1.24 ± 0.04, mean femoral neck BMD was 0.82 ± 0.00 g/cm and mean BMC was 4.37 ± 0.01 g. In the fully adjusted model, there was a negative correlation between DII with BMD (β = - 0.016, P < 0.001) and BMC (β = - 0.011, P < 0.001) in the most anti-inflammatory diet. Using BMI-stratified subgroup analysis, this correlation became more evident in both the overweight (BMD: β = - 0.024, P < 0.001; BMC: β = - 0.058, P = 0.042) and obese groups (BMD: β = - 0.015, P = 0.049; BMC: β = - 0.009, P = 0.042), while this correlation was opposite in DII tertile 2 (middle DII score) in the underweight group (BMD: β = 0.047, P = 0.038; BMC: β = 0.274, P = 0.010).
Relationship between higher consumption of pro-inflammatory and increased risk of lower BMD and BMC was only existed in overweight and obese participants.
骨质疏松症是一个主要的公共卫生问题。饮食炎症倾向和体重指数（BMI）是新兴的影响骨骼健康的因素。关于 BMI 和饮食状况对骨骼健康的综合影响，目前的证据有限。本研究旨在利用国家健康和营养检查调查（NHANES），研究不同 BMI 水平的成年人中膳食炎症指数（DII）与骨骼健康之间的关系。
数据来自 2005-2010 年、2013-2014 年至 2017-2018 年的 NHANES。共纳入了 10521 名年龄≥20 岁且完成了饮食摄入访谈、骨密度（BMD）和骨矿物质含量（BMC）完整数据的参与者。根据饮食摄入访谈，DII 用于评估饮食的炎症潜力。我们通过双能 X 射线吸收法测量股骨颈 BMD 和 BMC 来评估骨骼健康。采用加权多变量线性回归和 BMI 分层亚组分析。
10521 名参与者的平均 DII 评分为 1.24±0.04，平均股骨颈 BMD 为 0.82±0.00g/cm，平均 BMC 为 4.37±0.01g。在完全调整模型中，DII 与 BMD（β=-0.016，P<0.001）和 BMC（β=-0.011，P<0.001）呈负相关，在最抗炎饮食中。使用 BMI 分层亚组分析，在超重（BMD：β=-0.024，P<0.001；BMC：β=-0.058，P=0.042）和肥胖组（BMD：β=-0.015，P=0.049；BMC：β=-0.009，P=0.042）中，这种相关性变得更加明显，而在 BMI 三分位 2（中间 DII 评分）的消瘦组中，这种相关性则相反（BMD：β=0.047，P=0.038；BMC：β=0.274，P=0.010）。
在超重和肥胖参与者中，较高的促炎饮食摄入与较低的 BMD 和 BMC 风险增加之间存在关联。
