Mucellini Amanda B, Miguel Patrícia M, Dalle Molle Roberta, Rodrigues Danitsa M, Machado Tania D, Reis Roberta S, Toazza Rudinéia, Salum Giovanni A, Bortoluzzi Andressa, Franco Alexandre R, Buchweitz Augusto, Barth Barbara, Agranonik Marilyn, Nassim Marouane, Meaney Michael J, Manfro Gisele G, Silveira Patrícia P
Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Graduate Program in Neuroscience, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Appetite. 2022 Feb 1;169:105799. doi: 10.1016/j.appet.2021.105799. Epub 2021 Nov 9.
While classically linked to memory, the hippocampus is also a feeding behavior modulator due to its multiple interconnected pathways with other brain regions and expression of receptors for metabolic hormones. Here we tested whether variations in insulin sensitivity would be correlated with differential brain activation following exposure to palatable food cues, as well as with variations in implicit food memory in a cohort of healthy adolescents, some of whom were born small for gestational age (SGA). Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) was positively correlated with activation in the cuneus, and negatively correlated with activation in the middle frontal lobe, superior frontal gyrus and precuneus when presented with palatable food images versus non-food images in healthy adolescents. Additionally, HOMA-IR and insulinemia were higher in participants with impaired food memory. SGA individuals had higher snack caloric density and greater chance for impaired food memory. There was also an interaction between the HOMA-IR and birth weight ratio influencing external eating behavior. We suggest that diminished insulin sensitivity correlates with activation in visual attention areas and inactivation in inhibitory control areas in healthy adolescents. Insulin resistance also associated with less consistency in implicit memory for a consumed meal, which may suggest lower ability to establish a dietary pattern, and can contribute to obesity. Differences in feeding behavior in SGA individuals were associated with insulin sensitivity and hippocampal alterations, suggesting that cognition and hormonal regulation are important components involved in their food intake modifications throughout life.
虽然传统上认为海马体与记忆有关，但由于它与其他脑区有多个相互连接的通路以及代谢激素受体的表达，它也是一种进食行为调节因子。在此，我们测试了胰岛素敏感性的变化是否与接触美味食物线索后大脑的不同激活状态相关，以及与一组健康青少年的内隐食物记忆变化相关，其中一些青少年出生时为小于胎龄儿（SGA）。在健康青少年中，当呈现美味食物图像与非食物图像时，胰岛素抵抗的稳态模型评估（HOMA-IR）与楔叶的激活呈正相关，与额中回、额上回和楔前叶的激活呈负相关。此外，食物记忆受损的参与者的HOMA-IR和胰岛素血症更高。SGA个体的零食热量密度更高，食物记忆受损的可能性更大。HOMA-IR与出生体重比之间也存在相互作用，影响外在进食行为。我们认为，在健康青少年中，胰岛素敏感性降低与视觉注意力区域的激活以及抑制控制区域的失活相关。胰岛素抵抗还与进食一餐的内隐记忆缺乏一致性有关，这可能表明建立饮食模式的能力较低，并可能导致肥胖。SGA个体的进食行为差异与胰岛素敏感性和海马体改变有关，这表明认知和激素调节是其一生中食物摄入改变所涉及的重要组成部分。
