Bömelburg T, Ritter J, Schellong G
Klin Padiatr. 1987 May-Jun;199(3):230-2. doi: 10.1055/s-2008-1026795.
The methotrexate serum concentrations of 15 patients were measured in capillary and veneous blood samples. All of the patients had received methotrexate infusions because of their underlying oncologic disorder. The drug levels of 42 pairs of capillary and veneous drawn serum samples were analysed with a homogeneous enzyme immunoassay technique on a semi-automatic instrument system. In 15 pairs of samples the drug levels were below the range of the assay, in 3 they were just above. Here the capillary samples were measurable, whereas the veneous ones were not. 24 pairs of samples which had drug levels within the range of the assay showed a good correlation of capillary and veneous serum levels. The correlation factor of 0.934 shows, that the methotrexate concentrations can also be measured in capillary blood samples.
对15名患者的甲氨蝶呤血清浓度进行了毛细血管血样和静脉血样检测。所有患者均因潜在的肿瘤疾病接受了甲氨蝶呤输注。采用均相酶免疫分析技术，在半自动仪器系统上对42对毛细血管血样和静脉血样的药物水平进行了分析。15对样本的药物水平低于检测范围，3对略高于检测范围。在此情况下，毛细血管样本可检测到药物水平，而静脉样本则检测不到。24对药物水平在检测范围内的样本显示，毛细血管血样和静脉血样中的药物水平具有良好的相关性。相关系数为0.934，表明甲氨蝶呤浓度也可在毛细血管血样中进行检测。
