Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Research Center for Pharmaceutical Nanotechnology (RCPN), Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Mikrochim Acta. 2024 Oct 9;191(11):659. doi: 10.1007/s00604-024-06740-3.
Early detection of ovarian cancer (OC) is crucial for effective management and treatment, as well as reducing mortality rates. However, the current diagnostic methods for OC are time-consuming and have low accuracy. Surface plasmon resonance (SPR) biosensors offer a promising alternative to conventional techniques, as they enable rapid and less invasive screening of various circulating indicators. These biosensors are widely used for biomolecular interaction analysis and detecting tumor markers, and they are currently being investigated as a rapid diagnostic tool for early-stage cancer detection. Our main focus is on the fundamental concepts and performance characteristics of SPR biosensors. We also discuss the latest advancements in SPR biosensors that enhance their sensitivity and enable high-throughput quantification of OC biomarkers, including CA125, HE4, CEA, and CA19-9. Finally, we address the future challenges that need to be overcome to advance SPR biosensors from research to clinical applications. The ultimate goal is to facilitate the translation of SPR biosensors into routine clinical practice for the early detection and management of OC.
早期发现卵巢癌（OC）对于有效管理和治疗以及降低死亡率至关重要。然而，OC 的当前诊断方法既耗时又准确性低。表面等离子体共振（SPR）生物传感器为传统技术提供了一种有前途的替代方法，因为它们能够快速且微创地筛选各种循环指标。这些生物传感器广泛用于生物分子相互作用分析和检测肿瘤标志物，目前正被研究作为早期癌症检测的快速诊断工具。我们的主要重点是 SPR 生物传感器的基本概念和性能特征。我们还讨论了 SPR 生物传感器的最新进展，这些进展提高了它们的灵敏度，并能够高通量定量 OC 生物标志物，包括 CA125、HE4、CEA 和 CA19-9。最后，我们讨论了需要克服的未来挑战，以将 SPR 生物传感器从研究推进到临床应用。最终目标是促进 SPR 生物传感器转化为常规临床实践，以实现 OC 的早期检测和管理。
