Chang Wen-Dien, Chen Sheng-Hwa, Tsai Ming-Hsui, Tsou Yung-An
Department of Sport Performance, National Taiwan University of Sport, Taichung 404401, Taiwan.
Department of Audiology and Speech-Language Pathology, Asia University, Taichung 41354, Taiwan.
J Clin Med. 2021 Oct 28;10(21):5034. doi: 10.3390/jcm10215034.
Unilateral vocal palsy (UVFP) affects the voice and swallowing function and could be treated by various materials to achieve improved mucosal wave and better closure during phonation. Injection laryngoplasty is considered an exemplary method for these patients and could be injected as early as possible. We conducted a systematic review and meta-analysis for the subjective and objective outcomes of autologous fat injection laryngoplasty (AFIL) and assessed the effects for patients with UVFP.
We searched studies from PubMed and EBSCO databases with PRISMA appraisal to search for articles about the effects of AFIL on UVFP. The published articles were reviewed according to our inclusion and exclusion criteria. The short- and long-term outcomes of perceptual, acoustic analysis, and quality of life were also analyzed by meta-analysis.
Eleven articles were reviewed, and seven studies were selected for meta-analysis. AFIL improves the perceptual outcome and some voice parameters in short-term and long-term results, i.e., jitter, shimmer, and maximal phonation time (MPT). It also significantly improved the voice handicap index (VHI) in the long term, suggesting an increase in quality of life.
AFIL is considered a reliable treatment method for UVFP and could even last for over 12 months.
单侧声带麻痹（UVFP）会影响发声和吞咽功能，可通过多种材料进行治疗，以在发声时实现更好的黏膜波和闭合效果。注射喉成形术被认为是针对这些患者的一种典型方法，且可尽早进行注射。我们对自体脂肪注射喉成形术（AFIL）的主观和客观结果进行了系统评价和荟萃分析，并评估了其对UVFP患者的疗效。
我们使用PRISMA评估法在PubMed和EBSCO数据库中检索研究，以查找有关AFIL对UVFP疗效的文章。根据我们的纳入和排除标准对已发表的文章进行综述。还通过荟萃分析对感知、声学分析和生活质量的短期和长期结果进行了分析。
共综述了11篇文章，其中7项研究被选入荟萃分析。AFIL在短期和长期结果中均改善了感知结果和一些嗓音参数，即抖动、闪烁和最长发声时间（MPT）。从长期来看，它还显著改善了嗓音障碍指数（VHI），表明生活质量有所提高。
AFIL被认为是治疗UVFP的一种可靠方法，甚至可持续超过12个月。
