Jung Chang-Jin, Yang Hee-Joo, Bang Seung-Hyun, Lee Woo-Jin, Won Chong-Hyun, Lee Mi-Woo, Song Youngsup, Chang Sung-Eun
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea.
Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea.
J Clin Med. 2021 Nov 7;10(21):5200. doi: 10.3390/jcm10215200.
Several studies have determined the correlation between programmed cell death protein-1 (PD-1) and chronic plaque psoriasis (CPP). However, limited studies have assessed the association between PD-1 expression and the clinicoprognostic and distinct clinicopathological characteristics of CPP and guttate psoriasis (GP). Twenty-nine patients with skin biopsy-confirmed CPP were recruited at the Asan Medical Center between January 2018 and June 2020, and 33 patients with biopsy-confirmed GP were enrolled between January 2002 and June 2020. The clinicoprognostic and histopathological characteristics were analyzed according to immunohistochemical PD-1 expression in the epidermal or dermal inflammatory infiltrates. The CPP and GP lesions were divided into PD-1-low and PD-1-high groups. The CPP epidermal PD-1-high group had typical histopathological changes and significantly higher psoriasis area and severity index scores ( = 0.014) and disease duration ( = 0.009) than the epidermal PD-1-low group. In patients with GP, compared with the dermal PD-1-high group, the dermal PD-1-low group exhibited significantly higher disease duration ( = 0.002) and relapse rate of plaque psoriasis ( = 0.005) and significantly lower relapse-free survival ( = 0.016). Upregulated epidermal PD-1 expression was correlated with the chronicity and severity of CPP, while downregulated dermal PD-1 expression was correlated with poor prognosis of GP.
多项研究已确定程序性细胞死亡蛋白1（PD-1）与慢性斑块状银屑病（CPP）之间的相关性。然而，评估PD-1表达与CPP和点滴状银屑病（GP）的临床预后及不同临床病理特征之间关联的研究有限。2018年1月至2020年6月期间，在峨山医学中心招募了29例经皮肤活检确诊为CPP的患者，2002年1月至2020年6月期间招募了33例经活检确诊为GP的患者。根据表皮或真皮炎症浸润中免疫组化检测的PD-1表达情况，分析临床预后和组织病理学特征。将CPP和GP皮损分为PD-1低表达组和PD-1高表达组。CPP表皮PD-1高表达组具有典型的组织病理学改变，银屑病面积和严重程度指数评分（P = 0.014）及病程（P = 0.009）均显著高于表皮PD-1低表达组。在GP患者中，与真皮PD-1高表达组相比，真皮PD-1低表达组的病程（P = 0.002）和斑块状银屑病复发率（P = 0.005）显著更高，无复发生存率显著更低（P = 0.016）。表皮PD-1表达上调与CPP的慢性程度和严重程度相关，而真皮PD-1表达下调与GP的预后不良相关。
