Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Int J Mol Sci. 2021 Oct 21;22(21):11353. doi: 10.3390/ijms222111353.
The following research aims at the synthesis of magnetite nanoparticles functionalized with triazine-based dendrons and the application of the obtained materials as effective sorptive materials dedicated to acidic bioactive compounds. The adopted synthetic approach involved: (1) the synthesis of nanosized FeO particles via classic co-precipitation method, (2) the introduction of amine groups on their surface leading to materials' precursor, and (3) the final synthesis of branched triazine-based dendrons on the support surface by an iterative reaction between cyanuric chloride (CC) and piperazine (p) or diethylenetriamine (DETA) via nucleophilic substitution. The characterized materials were tested for their adsorptive properties towards folic acid, 18β-glycyrrhetinic acid, and vancomycin, showing high adsorption capacities varying in the ranges of 53.33-401.61, 75.82-223.71, and 68.17-132.45 mg g, respectively. The formed material-drug complexes were also characterized for the drug-delivery potential, performed as in vitro release studies at pH 2.0 and 7.4, which mimics the physiological conditions. The release profiles showed that the proposed materials are able to deliver up to 95.2% of the drugs within 48 h, which makes them efficient candidates for further biomedical applications.
本研究旨在合成基于三嗪的树枝状大分子功能化的磁铁矿纳米粒子，并将所得材料应用于作为有效吸附剂用于酸性生物活性化合物。所采用的合成方法包括：（1）通过经典共沉淀法合成纳米 FeO 颗粒，（2）在其表面引入胺基，得到材料前体，（3）通过氰尿酰氯（CC）和哌嗪（p）或二乙烯三胺（DETA）之间的亲核取代反应，在载体表面上最终合成支化的基于三嗪的树枝状大分子。对所表征的材料进行了对叶酸、18β-甘草次酸和万古霉素的吸附性能测试，表现出 53.33-401.61、75.82-223.71 和 68.17-132.45mg/g 的高吸附容量。还对形成的材料-药物复合物进行了药物传递潜力的表征，在 pH 2.0 和 7.4 下进行了体外释放研究，模拟生理条件。释放曲线表明，所提出的材料能够在 48 小时内释放高达 95.2%的药物，这使其成为进一步生物医学应用的有效候选者。
