Department of Food and Nutrition, College of Bionanotechnology, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea.
Korea Food Research Institute, Wanju-gun 55365, Jeollabuk-do, Korea.
Int J Mol Sci. 2021 Oct 25;22(21):11500. doi: 10.3390/ijms222111500.
Until now, several studies have looked at the issue of anthocyanin and cancer, namely the preventive and inhibitory effects of anthocyanins, as well as the underlying molecular processes. However, no targeted review is available regarding the anticarcinogenic effects of delphinidin and its glycosides on various cancers and their plausible molecular mechanisms. Considerable evidence shows significant anticancer properties of delphinidin-rich preparations and delphinidin alone both in vitro and in vivo. This review covers the in vitro and preclinical implications of delphinidin-mediated cell protection and cancer prevention; thus, we strongly recommend that delphinidin-rich preparations be further investigated as potential functional food, dietary antioxidant supplements, and natural health products targeting specific chronic diseases, including cancer. In addition to in vitro investigations, future research should focus on more animal and human studies to determine the true potential of delphinidin.
到目前为止，已有多项研究着眼于花色苷与癌症的问题，即花色苷的预防和抑制作用，以及潜在的分子过程。然而，针对飞燕草素及其糖苷对各种癌症的抗癌作用及其可能的分子机制，尚无靶向综述。大量证据表明，飞燕草素丰富的制剂和飞燕草素本身在体外和体内都具有显著的抗癌特性。本综述涵盖了飞燕草素介导的细胞保护和癌症预防的体外和临床前意义；因此，我们强烈建议进一步研究富含飞燕草素的制剂，将其作为针对特定慢性疾病（包括癌症）的功能性食品、膳食抗氧化补充剂和天然保健品。除了体外研究，未来的研究还应侧重于更多的动物和人体研究，以确定飞燕草素的真正潜力。
