Division of Thoracic and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, Auenbruggerplatz 29/3, 8036 Graz, Austria.
Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Auenbruggerplatz 29/2, 8036 Graz, Austria.
Int J Mol Sci. 2021 Oct 29;22(21):11754. doi: 10.3390/ijms222111754.
For more than six decades, hyperbaric oxygen (HBO) has been used for a variety of indications involving tissue repair. These indications comprise a wide range of diseases ranging from intoxications to ischemia-reperfusion injury, crush syndrome, central nervous injury, radiation-induced tissue damage, burn injury and chronic wounds. In a systematic review, the molecular mechanisms triggered by HBO described within the last two decades were compiled. They cover a wide range of pathways, including transcription, cell-to-cell contacts, structure, adhesion and transmigration, vascular signaling and response to oxidative stress, apoptosis, autophagy and cell death, as well as inflammatory processes. By analyzing 71 predominantly experimental publications, we established an overview of the current concepts regarding the molecular mechanisms underlying the effects of HBO. We considered both the abovementioned pathways and their role in various applications and indications.
六十多年来，高压氧（HBO）已被用于治疗多种涉及组织修复的疾病。这些适应证涵盖了从中毒到缺血再灌注损伤、挤压综合征、中枢神经系统损伤、放射性组织损伤、烧伤和慢性创面等广泛的疾病。在一项系统评价中，我们对过去二十年中描述的 HBO 触发的分子机制进行了总结。这些机制涵盖了广泛的途径，包括转录、细胞间接触、结构、黏附和迁移、血管信号以及对氧化应激、细胞凋亡、自噬和细胞死亡的反应，还有炎症过程。通过分析 71 篇主要的实验性文献，我们对 HBO 作用的分子机制的当前概念有了一个概述。我们既考虑了上述途径，也考虑了它们在各种应用和适应证中的作用。
