a Episomal-Persistent DNA in Cancer- and Chronic Diseases, Deutsches Krebsforschungszentrum , Heidelberg , Germany.
Emerg Microbes Infect. 2019;8(1):1205-1218. doi: 10.1080/22221751.2019.1651620.
The analyses of 109 replication-competent genomic DNA sequences isolated from cow milk and its products (97 in the bovine meat and milk factors 2 group - BMMF2, and additional 4 in BMMF1) seems to place these in a specific class of infectious agents spanning between bacterial plasmid and circular ssDNA viruses. Satellite-type small plasmids with partial homology to larger genomes, were also isolated in both groups. A member of the BMMF1 group H1MBS.1 was recovered in a distinctly modified form from colon tissue by laser microdissection. Although the evolutionary origin is unknown, it draws the attention to the existence of a hitherto unrecognized, broad spectrum of potential pathogens. Indirect hints to the origin and structure of our isolates, as well as to their replicative behaviour, result from parallels drawn to the Hepatitis deltavirus genome structure and replication.
从牛奶及其制品中分离出的 109 个复制型基因组 DNA 序列的分析结果（97 个在牛肌肉和奶因素 2 组-BMMF2，另外 4 个在 BMMF1）似乎将这些序列置于介于细菌质粒和环形单链 DNA 病毒之间的一类特定传染性病原体中。在这两个组中还分离到了与较大基因组具有部分同源性的卫星型小质粒。BMMF1 组的 H1MBS.1 成员通过激光微切割从结肠组织中以明显修饰的形式回收。虽然进化起源尚不清楚，但它引起了对尚未认识的广泛潜在病原体的关注。从与庚型肝炎病毒基因组结构和复制的相似之处中得出了我们的分离物的起源和结构及其复制行为的间接提示。
