Duke Molecular Physiology Institute, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.
Division of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Curr Opin Anaesthesiol. 2022 Feb 1;35(1):42-47. doi: 10.1097/ACO.0000000000001077.
Due to the growing mismatch between donor supply and demand as well as unacceptably high transplant waitlist mortality, the heart organ allocation system was revised in October 2018. This review gives an overview of the changes in the new heart organ allocation system and its impact on heart transplant practice and outcomes in the United States.
The 2018 heart allocation system offers a 6-tiered policy and therefore prioritizes the sickest patients on the transplant waitlist. Patients supported with temporary mechanical circulatory support devices are prioritized as Status 1 or Status 2, resulting in increased utilization of this strategy. Patients supported with durable left ventricular assist devices have been prioritized as Status 3 or 4, which has resulted in decreased utilization of this strategy. Broader geographic sharing in the new heart allocation system has resulted in prolonged donor ischemic times. Overall, the new heart allocation system has resulted in significantly lower candidate waitlist mortality, shorter waitlist times, and higher incidence of transplantation.
The new United Network for Organ Sharing allocation policy confers significant advantages over the prior algorithm, allowing for decreased waitlist times and improved waitlist mortality without major impact on posttransplant survival.
目的综述:由于供体供应与需求之间的差距不断扩大以及移植候补者死亡率高得令人无法接受,心脏器官分配系统于 2018 年 10 月进行了修订。本综述概述了新的心脏器官分配系统的变化及其对美国心脏移植实践和结果的影响。
最近的发现:2018 年的心脏分配系统采用了六级政策,因此优先考虑移植候补名单上病情最严重的患者。接受临时机械循环支持设备支持的患者被优先列为 1 级或 2 级,从而增加了这种策略的使用。接受耐用性左心室辅助装置支持的患者被优先列为 3 级或 4 级,这导致了这种策略的使用减少。新的心脏分配系统中更广泛的地理共享导致供体缺血时间延长。总体而言,新的心脏分配系统显著降低了候选者候补名单死亡率,缩短了候补名单时间,并提高了移植率。
总结:新的美国器官共享网络分配政策与之前的算法相比具有显著优势,在不影响移植后生存率的情况下,减少了候补名单时间并提高了候补名单死亡率。