Department of Cardiology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Center for Translational Medicine, The Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Cardio-macrovascular Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou, China.
Environ Sci Pollut Res Int. 2022 Mar;29(15):21851-21859. doi: 10.1007/s11356-021-17423-4. Epub 2021 Nov 12.
The aim is to examine the environmental exposure to perchlorate, nitrate, and thiocyanate and their associations with all-cause and cause-specific mortality in a general population. A total of 17,982 participants were enrolled from the National Health and Nutrition Examination Survey and urinary perchlorate, nitrate, and thiocyanate are measured using ion chromatography coupled with electrospray tandem mass spectrometry. Multivariable linear and logistic regression models were performed to explore the associations between urinary perchlorate, nitrate, and thiocyanate with all-cause and cause-specific mortality. Restricted cubic spline models were used to explore the nonlinearity. During a 7.5-year of follow-up, 1730 deaths occurred. Kaplan-Meier analysis suggested that urinary perchlorate, thiocyanate, and nitrate were associated with all-cause mortality (all log-rank P<0.001). After adjusted for traditional risk factors, we found that urinary perchlorate was inversely associated with cancer mortality (hazard ratio [HR] 0.87; 95% confidence interval [0.76, 0.99]; P=0.038) while nitrate was positively related to cancer mortality (HR 1.19, [1.05, 1.34]; P=0.006). Besides, urinary thiocyanate exposure was U-shape associated with the risk of all-cause mortality (P for nonlinearity<0.001). Urinary perchlorate was inversely while nitrate was positively associated with the risk of cancer mortality. The thiocyanate exposure was U-shape associated with the risk of all-cause mortality.
目的在于研究人群中全因死亡率和特定原因死亡率与高氯酸盐、硝酸盐和硫氰酸盐的环境暴露及其相关性。本研究共纳入了 17982 名来自全国健康和营养调查的参与者，采用离子色谱-电喷雾串联质谱法检测尿液中的高氯酸盐、硝酸盐和硫氰酸盐。多变量线性和逻辑回归模型用于探索尿液中高氯酸盐、硝酸盐和硫氰酸盐与全因死亡率和特定原因死亡率之间的关系。受限立方样条模型用于探索非线性关系。在 7.5 年的随访期间，共发生了 1730 例死亡。Kaplan-Meier 分析表明，尿液中的高氯酸盐、硫氰酸盐和硝酸盐均与全因死亡率相关（所有 log-rank P<0.001）。在调整了传统危险因素后，我们发现尿液中的高氯酸盐与癌症死亡率呈负相关（风险比 [HR] 0.87；95%置信区间 [0.76, 0.99]；P=0.038），而硝酸盐与癌症死亡率呈正相关（HR 1.19，[1.05, 1.34]；P=0.006）。此外，尿液中硫氰酸盐的暴露与全因死亡率的风险呈 U 型相关（非线性 P<0.001）。尿液中的高氯酸盐与癌症死亡率呈负相关，而硝酸盐与癌症死亡率呈正相关。硫氰酸盐的暴露与全因死亡率的风险呈 U 型相关。
