Yuan Wei, Wang Ruzhu, Song Guixian, Ruan Zhongbao, Zhu Li, Zhang Wei
Department of Cardiology, Taizhou People's Hospital, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, 225300, Jiangsu, China.
Department of Oncology, Taizhou People's Hospital, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, 225300, Jiangsu, China.
Environ Sci Pollut Res Int. 2023 Jan;30(5):13697-13701. doi: 10.1007/s11356-022-23036-2. Epub 2022 Sep 22.
Perchlorate, nitrate, and thiocyanate are reported to affect human health. However, it is unclear about the associations between exposure to these chemicals and abdominal aortic calcification (AAC). A total of 959 individuals were included in a large representative survey. Urinary levels of perchlorate, nitrate, and thiocyanate were measured by ion chromatography coupled with electrospray tandem mass spectrometry. AAC was diagnosed based on dual-energy X-ray absorptiometry (DXA). There were 276 (28.8%) cases of AAC among the participants. The level of urinary nitrate was significantly lower in AAC patients compared with non-AAC patients (36.4 mg/L [20.6, 59.5] vs. 42.4 [23.8, 68.3]; P = 0.013). In multivariable-adjusted logistic regression models, urinary nitrate was associated with the prevalence of AAC. Compared with the lowest quartile, the odds ratios (95% confidence intervals) across increasing quartiles were 1.06 (0.69-1.61; P = 0.799), 0.64 (0.41-1.00; P = 0.049) and 0.74 (0.47-1.15; P = 0.180). Restricted cubic splines suggested that urinary nitrate ranging between 43.7 and 115.4 mg/L was associated with a lower risk of AAC. Moderate exposure to nitrate was associated with a lower risk of AAC.
据报道，高氯酸盐、硝酸盐和硫氰酸盐会影响人体健康。然而，目前尚不清楚接触这些化学物质与腹主动脉钙化（AAC）之间的关联。一项大型代表性调查共纳入了959名个体。采用离子色谱-电喷雾串联质谱法测定尿中高氯酸盐、硝酸盐和硫氰酸盐的水平。基于双能X线吸收法（DXA）诊断腹主动脉钙化。参与者中共有276例（28.8%）腹主动脉钙化病例。与非腹主动脉钙化患者相比，腹主动脉钙化患者的尿硝酸盐水平显著降低（36.4mg/L[20.6,59.5] vs. 42.4[23.8,68.3]；P=0.013）。在多变量调整逻辑回归模型中，尿硝酸盐与腹主动脉钙化的患病率相关。与最低四分位数相比，随着四分位数增加，比值比（95%置信区间）分别为1.06（0.69-1.61；P=0.799）、0.64（0.41-1.00；P=0.049）和0.74（0.47-1.15；P=0.180）。受限立方样条显示，尿硝酸盐水平在43.7至115.4mg/L之间与腹主动脉钙化风险较低相关。适度接触硝酸盐与腹主动脉钙化风险较低相关。
