成年和老年小鼠派尔集合淋巴结中淋巴细胞和巨噬细胞群体的膜及功能特性
Membrane and functional characterization of lymphoid and macrophage populations of Peyer's patches from adult and aged mice.
作者信息
Vĕtvicka V, Tlaskalová-Hogenová H, Fornůsek L, Ríhová B, Holán V
机构信息
Institute of Microbiology, Czechoslovak Academy of Sciences, Prague.
出版信息
Immunology. 1987 Sep;62(1):39-43.
Properties of macrophages isolated from Peyer's patches were compared with properties of peritoneal macrophages. We found a very low expression of all types of Fc receptors as well as a low expression of Ia antigens on Peyer's patch macrophages. No substantial changes in the levels of FcR and Ia antigen expression were found during the process of ageing. The investigation of phagocytic activity showed the activated state of Peyer's patch macrophages. Comparing the surface markers of lymphocytes obtained from Peyer's patches of mice of different ages, we found no differences in the numbers of sIg+, Thy-+ or L3T4+ lymphocytes. The numbers of FcR+ and Lyt 2.2+ lymphocytes decreased markedly with age.
将从派尔集合淋巴结分离出的巨噬细胞的特性与腹膜巨噬细胞的特性进行了比较。我们发现，派尔集合淋巴结巨噬细胞上所有类型的Fc受体表达水平都非常低，Ia抗原的表达水平也很低。在衰老过程中，未发现FcR和Ia抗原表达水平有实质性变化。吞噬活性研究表明派尔集合淋巴结巨噬细胞处于激活状态。比较不同年龄小鼠派尔集合淋巴结中获得的淋巴细胞的表面标志物，我们发现sIg +、Thy - +或L3T4 +淋巴细胞数量没有差异。FcR +和Lyt 2.2 +淋巴细胞的数量随年龄显著减少。
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