'长新冠'：一项针对 COVID-19 住院后持续症状、生物标志物和影像学异常的横断面研究。
'Long-COVID': a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19.
机构信息
Respiratory Medicine, Royal Free London NHS Foundation Trust, London, UK.
Department of Radiology, Royal Free London NHS Foundation Trust, London, UK.
出版信息
Thorax. 2021 Apr;76(4):396-398. doi: 10.1136/thoraxjnl-2020-215818. Epub 2020 Nov 10.
Abstract
Large numbers of people are being discharged from hospital following COVID-19 without assessment of recovery. In 384 patients (mean age 59.9 years; 62% male) followed a median 54 days post discharge, 53% reported persistent breathlessness, 34% cough and 69% fatigue. 14.6% had depression. In those discharged with elevated biomarkers, 30.1% and 9.5% had persistently elevated d-dimer and C reactive protein, respectively. 38% of chest radiographs remained abnormal with 9% deteriorating. Systematic follow-up after hospitalisation with COVID-19 identifies the trajectory of physical and psychological symptom burden, recovery of blood biomarkers and imaging which could be used to inform the need for rehabilitation and/or further investigation.
摘要
大量 COVID-19 患者出院时并未进行康复评估。在中位随访时间为 54 天的 384 名患者中，53%报告持续呼吸困难，34%咳嗽，69%疲劳。14.6%有抑郁症状。出院时生物标志物升高的患者中，分别有 30.1%和 9.5%的人 d-二聚体和 C 反应蛋白持续升高。38%的胸部 X 线片仍异常，9%的患者恶化。对 COVID-19 住院患者进行系统随访，可以确定身体和心理症状负担、血液生物标志物和影像学恢复的轨迹，从而可以为康复和/或进一步检查提供依据。
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