Zhao Yan, Huang Zineng, Peng Hongling
Department of Hematology, The Second Xiangya Hospital, Hunan Key Laboratory of Basic and Applied Hematology, Central South University, Changsha, China.
Institute of Hematology, Central South University, Changsha, China.
Front Oncol. 2021 Oct 27;11:743006. doi: 10.3389/fonc.2021.743006. eCollection 2021.
Cell death is essential for the normal metabolism of human organisms. Ferroptosis is a unique regulated cell death (RCD) mode characterized by excess accumulation of iron-dependent lipid peroxide and reactive oxygen species (ROS) compared with other well-known programmed cell death modes. It has been currently recognized that ferroptosis plays a rather important role in the occurrence, development, and treatment of traumatic brain injury, stroke, acute kidney injury, liver damage, ischemia-reperfusion injury, tumor, etc. Of note, ferroptosis may be explained by the expression of various molecules and signaling components, among which iron, lipid, and amino acid metabolism are the key regulatory mechanisms of ferroptosis. Meanwhile, tumor cells of hematological malignancies, such as leukemia, lymphoma, and multiple myeloma (MM), are identified to be sensitive to ferroptosis. Targeting potential regulatory factors in the ferroptosis pathway may promote or inhibit the disease progression of these malignancies. In this review, a systematic summary was conducted on the key molecular mechanisms of ferroptosis and the current potential relationships of ferroptosis with leukemia, lymphoma, and MM. It is expected to provide novel potential therapeutic approaches and targets for hematological malignancies.
细胞死亡对人类机体的正常新陈代谢至关重要。铁死亡是一种独特的程序性细胞死亡（RCD）模式，与其他众所周知的程序性细胞死亡模式相比，其特征在于铁依赖性脂质过氧化物和活性氧（ROS）的过度积累。目前已经认识到，铁死亡在创伤性脑损伤、中风、急性肾损伤、肝损伤、缺血再灌注损伤、肿瘤等疾病的发生、发展和治疗中起着相当重要的作用。值得注意的是，铁死亡可以通过各种分子和信号成分的表达来解释，其中铁、脂质和氨基酸代谢是铁死亡的关键调节机制。同时，白血病、淋巴瘤和多发性骨髓瘤（MM）等血液系统恶性肿瘤的肿瘤细胞被确定对铁死亡敏感。靶向铁死亡途径中的潜在调节因子可能会促进或抑制这些恶性肿瘤的疾病进展。在本综述中，对铁死亡的关键分子机制以及铁死亡与白血病、淋巴瘤和MM之间目前的潜在关系进行了系统总结。期望为血液系统恶性肿瘤提供新的潜在治疗方法和靶点。
