European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge.
Protein Sci. 2022 Jan;31(1):283-289. doi: 10.1002/pro.4238. Epub 2021 Nov 24.
The PDBsum web server provides structural analyses of the entries in the Protein Data Bank (PDB). Two recent additions are described here. The first is the detailed analysis of the SARS-CoV-2 virus protein structures in the PDB. These include the variants of concern, which are shown both on the sequences and 3D structures of the proteins. The second addition is the inclusion of the available AlphaFold models for human proteins. The pages allow a search of the protein against existing structures in the PDB via the Sequence Annotated by Structure (SAS) server, so one can easily compare the predicted model against experimentally determined structures. The server is freely accessible to all at http://www.ebi.ac.uk/pdbsum.
PDBsum 网络服务器提供蛋白质数据银行 (PDB) 中条目的结构分析。此处描述了两个最近的新增功能。第一个是对 PDB 中 SARS-CoV-2 病毒蛋白结构的详细分析。这些结构包括关切变体，它们在蛋白质的序列和 3D 结构上均有显示。第二个新增功能是包含可用于人类蛋白质的可用 AlphaFold 模型。这些页面允许通过结构序列注释 (SAS) 服务器对蛋白质进行搜索，以便可以轻松地将预测模型与实验确定的结构进行比较。该服务器可免费在 http://www.ebi.ac.uk/pdbsum 上访问。
