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血浆氨基酸谱,一种可以替代腰围的日本人内脏脂肪组织的生物标志物。

Plasma amino acid profile, a biomarker for visceral adipose tissue that can substitute for waist circumference in Japanese Americans.

机构信息

Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.

Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA; Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA.

出版信息

Obes Res Clin Pract. 2021 Nov-Dec;15(6):557-563. doi: 10.1016/j.orcp.2021.10.007. Epub 2021 Nov 12.

Abstract

BACKGROUND

Greater visceral fat area (VFA) is associated with cardiometabolic outcomes. We sought to identify cross-sectional and longitudinal associations between amino acid (AA) levels and VFA in Japanese-Americans.

METHODS

From the cohort of 342 Japanese-American participants (51% men) in a study of diabetes risk factors who were free from diabetes, we measured levels of 20 AA by mass spectrometry, height, weight, waist circumference (WC), VFA, subcutaneous fat area by single-slice CT at the umbilicus. Using AA significantly associated with VFA in univariate analyses, we created a VFA prediction index, termed the 4A index. We compared area under receiver-operating characteristic curve (AUROC) of the 4A index to WC and an existing AA index (Yamakado et al. Clin Obes 2012) in classifying VFA at different cutoff values. We fit age-adjusted linear regression models to evaluate associations between AA levels and change in VFA over 5 years.

RESULTS

All 20 AA levels significantly detected VFA excess, but WC was better. The 4A index performed better than Yamakado index at classifying VFA ≥ 100 cm (0.798, 0.807 vs. 0.677, 0.671 for men and women, p < 0.0033) and VFA ≥ sex-specific median values (0.797, 0.786 vs. 0.676, 0.629 for men and women, p < 0.0017). AA significantly associated with change in VFA over 5 years were asparagine, glutamate, glutamine, glycine, methionine, proline, threonine in men; and histidine, isoleucine, tyrosine in women (p < 0.05).

CONCLUSIONS

The 4A index can serve as a biomarker for VFA in Japanese-Americans and be considered for this purpose when WC is not available.

摘要

背景

内脏脂肪面积(VFA)较大与心血管代谢结局相关。我们旨在确定氨基酸(AA)水平与日本裔美国人 VFA 之间的横断面和纵向关联。

方法

在一项糖尿病危险因素研究中,我们从 342 名无糖尿病的日本裔参与者队列中(51%为男性),通过质谱法测量了 20 种 AA 的水平、身高、体重、腰围(WC)、脐部单层面 CT 测量的 VFA 和皮下脂肪面积。使用单变量分析中与 VFA 显著相关的 AA,我们创建了一个 VFA 预测指数,称为 4A 指数。我们比较了 4A 指数与 WC 和现有 AA 指数(Yamakado 等人,Clin Obes 2012 年)在不同截断值下分类 VFA 的曲线下面积(AUROC)。我们拟合了年龄调整的线性回归模型,以评估 AA 水平与 5 年内 VFA 变化之间的关系。

结果

所有 20 种 AA 水平均显著检测到 VFA 过多,但 WC 更好。4A 指数在分类 VFA≥100cm(男性和女性分别为 0.798、0.807 与 0.677、0.671,p<0.0033)和 VFA≥性别特异性中位数(男性和女性分别为 0.797、0.786 与 0.676、0.629,p<0.0017)方面优于 Yamakado 指数。5 年内 VFA 变化与 AA 显著相关的是男性的天冬酰胺、谷氨酸、谷氨酰胺、甘氨酸、蛋氨酸、脯氨酸、苏氨酸;女性的组氨酸、异亮氨酸、酪氨酸(p<0.05)。

结论

4A 指数可作为日本裔美国人 VFA 的生物标志物,当 WC 不可用时,可考虑用于此目的。

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