Department of Pharmacology, School of Medical Sciences, University of Campinas, Campinas, 13083-887, Brazil.
Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, 13083-887, Brazil.
Biomark Med. 2021 Dec;15(18):1785-1795. doi: 10.2217/bmm-2021-0348. Epub 2021 Nov 17.
miRNAs are potential biomarkers of several diseases. This review aimed to identify the miRNAs that could serve as biomarkers of COVID-19. A literature search of nine databases was carried out for studies published before 13 June 2021 that described dysregulated miRNAs in cells or animals infected by SARS-CoV-2 or in patients with COVID-19. Two independent reviewers selected the studies and extracted data; disagreements were resolved by a third reviewer. Twenty studies were included in this scoping review; results suggested that miR-21-5p, miR-146a, miR-126-3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19. miRNAs appear to play key roles in viral replication, proliferation of infected cells, immune response, inflammation and cardiovascular dysfunction. This review provides insights into the role of miRNAs as biomarkers in COVID-19 and the current status and future directions for research in this field.
miRNAs 是多种疾病的潜在生物标志物。本综述旨在确定可作为 COVID-19 生物标志物的 miRNAs。对截至 2021 年 6 月 13 日描述了 SARS-CoV-2 感染的细胞或动物中失调的 miRNAs 或 COVID-19 患者中失调的 miRNAs 的研究进行了九种数据库的文献检索。两名独立的综述作者选择了研究并提取了数据；分歧由第三名综述作者解决。这项范围综述纳入了 20 项研究；结果表明，miR-21-5p、miR-146a、miR-126-3p、miR-144 和 miR-155 是最重要的失调 miRNAs，可作为诊断和指示 COVID-19 严重程度的生物标志物。miRNAs 似乎在病毒复制、受感染细胞的增殖、免疫反应、炎症和心血管功能障碍中发挥关键作用。本综述提供了对 miRNAs 作为 COVID-19 生物标志物的作用的深入了解，以及该领域研究的现状和未来方向。
