University of Eastern Piedmont, Department of Pharmaceutical Sciences, Largo Donegani 2, 28100 Novara, Italy.
R&D Department, Indena SpA, via Don Minzoni 6, 20090 Settala, (MI), Italy.
Fitoterapia. 2022 Jan;156:105084. doi: 10.1016/j.fitote.2021.105084. Epub 2021 Nov 14.
The stability of molecular curcumin (purcumin, 1a) in solution is strongly light-dependent. Under laboratory artificial light, a relative stability is observed only at neutral pH, while more intense light and/or solar light can trigger degradation via a combination of hydrolytic and oxidative fragmentation of the heptadiendione moiety. Minor curcuminoids in commercial curcumin (purcuminoids) can improve the stability of molecular curcumin, but only under conditions of low irradiation. While confirming earlier observations alerting to the instability of purcumin, our results provide new rationales for unexplained differences between previous studies, question the biological relevance of a non-enzymatic degradation for the bioactivity profiles that have been reported for purcumin, and highlight the need of a better characterization of the degradation of purcuminoids under visible light irradiation.
分子姜黄素（朴若木，1a）在溶液中的稳定性强烈依赖于光。在实验室人工光下，仅在中性 pH 值下观察到相对稳定性，而更强的光和/或太阳光可以通过七烯二酮部分的水解和氧化断裂的组合触发降解。商业姜黄素（朴若木素）中的微量姜黄素可以提高分子姜黄素的稳定性，但仅在低辐射条件下。虽然证实了早期的观察结果，即朴若木的不稳定性，但我们的结果为以前研究中未解释的差异提供了新的依据，质疑了非酶降解对已报道的朴若木生物活性谱的生物学相关性，并强调了需要更好地描述朴若木素在可见光照射下的降解情况。
