全球临床分离大肠杆菌中介导粘菌素耐药的 mcr 流行状况及分子流行病学：系统综述
Global prevalence and molecular epidemiology of mcr-mediated colistin resistance in Escherichia coli clinical isolates: a systematic review.
机构信息
Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran; Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Department of Microbiology, School of Medicine, Shahed University, Tehran, Iran.
出版信息
J Glob Antimicrob Resist. 2022 Jun;29:444-461. doi: 10.1016/j.jgar.2021.10.022. Epub 2021 Nov 14.
OBJECTIVES
The continuing rise in infections caused by multidrug-resistant (MDR) bacteria is one of the most serious public-health issues in society today. Colistin is a last-resort antimicrobial drug used to treat infections caused by MDR Gram-negative bacteria, therefore resistance to this antibiotic is extremely hazardous. The current study aimed to evaluate the global prevalence nd distribution of colistin resistance genes among human clinical isolates of Escherichia coli by systematic review.
METHODS
PubMed, Embase and Web of Science databases were systematically searched. For further evaluation, all original English language articles that reported colistin resistance in E. coli clinical isolates published between 2000 and 2020 were examined.
RESULTS
Of 4857 initial articles, after various stages of review and evaluation 190 related articles were selected for the systematic review. More than 79% of the publications selected in this research were published from 2014-2020. In Asia, Europe, America, Africa and Oceania, the prevalence of mobile colistin resistance (mcr)-harbouring colistin-resistant E. coli was 66.72%, 25.49%, 5.19%, 2.27% and 0.32 %, respectively.
CONCLUSION
The recent widespread dissemination of E. coli strains harbouring mcr genes conferring colistin resistance, especially in Asia and Europe, is concerning and requires more attention.
目的
由耐多药（MDR）细菌引起的感染不断上升，是当今社会最严重的公共卫生问题之一。黏菌素是一种用于治疗 MDR 革兰氏阴性菌感染的最后手段抗菌药物，因此对这种抗生素的耐药性极其危险。本研究旨在通过系统评价评估全球人类临床分离的大肠埃希菌中黏菌素耐药基因的流行率和分布。
方法
系统检索了 PubMed、Embase 和 Web of Science 数据库。为了进一步评估，我们检查了所有报告 2000 年至 2020 年间大肠埃希菌临床分离株对黏菌素耐药的原始英文文章。
结果
在最初的 4857 篇文章中，经过不同阶段的审查和评估，选择了 190 篇相关文章进行系统评价。本研究中选择的出版物中超过 79%是在 2014-2020 年发表的。在亚洲、欧洲、美洲、非洲和大洋洲，携带移动性黏菌素耐药（mcr）基因的黏菌素耐药大肠埃希菌的流行率分别为 66.72%、25.49%、5.19%、2.27%和 0.32%。
结论
最近 mcr 基因携带黏菌素耐药基因的大肠埃希菌菌株广泛传播，特别是在亚洲和欧洲，令人担忧，需要引起更多关注。
Zotero 插件