Department of Anesthesiology, Montefiore Medical Center, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
Clin Pediatr (Phila). 2022 Feb;61(2):159-167. doi: 10.1177/00099228211059883. Epub 2021 Nov 18.
In this retrospective study of 319 children with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we assessed whether age, asthma, obesity, diabetes, and socioeconomic status were associated with hospitalization for coronavirus disease 2019 (COVID-19). Demographic and clinical characteristics were assessed using univariate statistics, excluding incidental or unrelated positives. There was a bimodal distribution of age among hospitalized children. Obesity ( < .001) and a past medical history of diabetes ( = .001) were significantly more prevalent in hospitalized children, including cases of new-onset diabetes and diabetic ketoacidosis. Neither a past medical history of asthma nor lower socioeconomic status was associated with hospitalization. Although limited to a single center, the findings in this study may have important clinical implications. Targeted, proactive health outreach to children with obesity and diabetes, with prioritization of preventative efforts such as vaccination, may be important in preventing worse SARS-CoV-2 infection in this vulnerable group.
在这项针对 319 名实验室确诊的严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）感染儿童的回顾性研究中，我们评估了年龄、哮喘、肥胖、糖尿病和社会经济地位是否与 2019 年冠状病毒病（COVID-19）住院有关。使用单变量统计方法评估人口统计学和临床特征，排除偶然或无关的阳性结果。住院儿童的年龄呈双峰分布。肥胖症（<0.001）和糖尿病既往病史（=0.001）在住院儿童中更为普遍，包括新发糖尿病和糖尿病酮症酸中毒病例。哮喘既往病史或社会经济地位较低与住院治疗均无关。尽管本研究仅限于单个中心，但这些发现可能具有重要的临床意义。针对肥胖症和糖尿病儿童进行有针对性的、积极主动的健康宣传，优先进行疫苗接种等预防措施，可能对预防这一脆弱群体的 SARS-CoV-2 感染恶化具有重要意义。
