Cui Naixue, Raine Adrian, Connolly Cynthia A, Richmond Therese S, Hanlon Alexandra L, McDonald Catherine C, Liu Jianghong
School of Nursing and Rehabilitation, Shandong University, Jinan, China.
Department of Family and Community Health, School of Nursing, University of Pennsylvania, Philadelphia, PA, United States.
Front Psychol. 2021 Nov 1;12:720094. doi: 10.3389/fpsyg.2021.720094. eCollection 2021.
The psychophysiological mechanism linking early childhood experiences to behavior problems remains unclear. This study aimed to examine the association of child physical abuse with P300 event-related potentials (ERP), and to test the mediating effect of P300 amplitude and latency in the relationship between child physical abuse and externalizing behaviors. Cross-sectional secondary data were obtained from 155 children (55.5% boys, mean age: 11.28 ± 0.57 years) who participated in the China Jintan Child Cohort Study. Children self-reported maternal and paternal physical abuse and externalizing behaviors, as well as P300 were obtained in 2013. Additionally, parents and teachers reported child externalizing behaviors in preschool in 2007. P300 were recorded during a standard novel auditory oddball task. Path analysis shows that after controlling for child sex, socioeconomic status, area of residence, IQ, and child externalizing behavior in preschool, children exposed to maternal physical abuse exhibited increased novelty P300 amplitude, which links to more externalizing behavior. Novelty P300 amplitude partially mediated the relationship between maternal physical abuse and externalizing behavior. These findings are the first to document the partial mediating effect of P300 amplitude on the abuse-externalizing relationship and are consistent with the view that physical abuse affects the attention bias to novel cues that likely places them at increased risk for the development and maintenance of externalizing behavior.
将儿童早期经历与行为问题联系起来的心理生理机制仍不清楚。本研究旨在探讨儿童身体虐待与P300事件相关电位（ERP）之间的关联，并检验P300波幅和潜伏期在儿童身体虐待与外化行为关系中的中介作用。横断面二手数据来自155名儿童（55.5%为男孩，平均年龄：11.28±0.57岁），他们参与了中国金坛儿童队列研究。儿童自我报告了父母的身体虐待和外化行为，以及2013年获得的P300。此外，父母和教师报告了2007年儿童在学龄前的外化行为。P300是在标准的新奇听觉oddball任务中记录的。路径分析表明，在控制了儿童性别、社会经济地位、居住地区、智商和儿童学龄前外化行为后，遭受母亲身体虐待的儿童表现出新奇P300波幅增加，这与更多的外化行为有关。新奇P300波幅部分介导了母亲身体虐待与外化行为之间的关系。这些发现首次记录了P300波幅在虐待与外化关系中的部分中介作用，并且与身体虐待影响对新奇线索的注意偏向这一观点一致，而这种注意偏向可能使他们在发展和维持外化行为方面面临更高的风险。
