Etefa Monenus, Beyi Ashenafi Feyisa, Ayana Dinka, Beyene Tariku Jibat, Tufa Takele Beyene
Jimma University, College of Agriculture and Veterinary Medicine, Jimma, Ethiopia.
Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011, USA.
Vet Med Int. 2021 Nov 8;2021:6669036. doi: 10.1155/2021/6669036. eCollection 2021.
The rational use of drugs in veterinary medicine has various significances, such as reducing the risk of drug resistance, increasing efficacy, reducing drug residue, and decreasing adverse drug reactions. A retrospective study was conducted to assess veterinary drug prescribing practices at Batu and Arsi-Negelle district veterinary clinics in the rift valley areas of Ethiopia. A total of 2,464 cases were recorded from the case registration books at both the clinics for diseases treated between September 2012 and February 2015. The study results showed that for a total of 2,464 cases diagnosed at both clinics, 3,811 different drugs were prescribed, with an average per encounter of 1.6. Among the total drugs, oxytetracycline, ivermectin, penstrep, sulfa drugs, and albendazole were the most leading prescribed drugs with a frequency of 43.0%, 17.6%, 10.2%, 6.5%, and 1.3%, respectively. All drugs were prescribed by the generic name without any laboratory support of the disease. About 68.3% of the cases were diagnosed by unspecified professionals, whereas 21.7% and 10.1% were done by animal health assistants and veterinarians, respectively. The prescribing practices showed 61.0% of antibiotics and 29.7% of anthelmintics where 45.3% and 54.7% of antibiotics and 17.8% and 82.2% of anthelmintics were given at Batu and Arsi-Negelle veterinary clinics, respectively. Of the prescribed drugs, 4.6% oxytetracycline and 2.6% penstrep were prescribed irrationally to treat diseases that were tentatively diagnosed as parasitic cases. Similarly, 40.5% ivermectin and 17.7% albendazole were prescribed for bacterial infections. In conclusion, this study revealed problems in antibiotics and anthelmintics use, description of routes of administration and length of treatment, and shortage of laboratory diagnostic facilities. Therefore, veterinary drugs, particularly antibiotics and anthelmintics, should be used appropriately to safeguard the public from residual drug impacts and resistance development.
兽药的合理使用具有多种意义,如降低耐药风险、提高疗效、减少药物残留以及降低药物不良反应。开展了一项回顾性研究,以评估埃塞俄比亚裂谷地区巴图和阿尔西-内盖勒地区兽医诊所的兽药处方做法。从两家诊所2012年9月至2015年2月治疗疾病的病例登记册中总共记录了2464例病例。研究结果表明,在两家诊所诊断的总共2464例病例中,共开出了3811种不同的药物,每次就诊平均用药1.6种。在所有药物中,土霉素、伊维菌素、青霉素链霉素、磺胺类药物和阿苯达唑是最常用的处方药,使用频率分别为43.0%、17.6%、10.2%、6.5%和1.3%。所有药物均以通用名开具,没有任何疾病的实验室支持。约68.3%的病例由未指定的专业人员诊断,而动物健康助理和兽医分别诊断了21.7%和10.1%的病例。处方做法显示,抗生素占61.0%,驱虫药占29.7%,其中巴图和阿尔西-内盖勒兽医诊所抗生素的使用比例分别为45.3%和54.7%,驱虫药的使用比例分别为17.8%和82.2%。在所开药物中,4.6%的土霉素和2.6%的青霉素链霉素被不合理地用于治疗初步诊断为寄生虫病例的疾病。同样,40.5%的伊维菌素和17.7%的阿苯达唑被用于细菌感染。总之,本研究揭示了抗生素和驱虫药使用、给药途径和治疗时长描述以及实验室诊断设施短缺等问题。因此,应合理使用兽药,特别是抗生素和驱虫药,以保护公众免受药物残留影响和耐药性发展的危害。