Adamski Jan, Jäschke Björn, Nieminen Tuomas, Weigl Wojciech
Department of Anaesthesiology and Intensive Care, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Department of Anaesthesiology and Intensive Care, Satakunta Central Hospital, Pori, Finland.
Eur J Case Rep Intern Med. 2021 Oct 12;8(10):002759. doi: 10.12890/2021_002842. eCollection 2021.
We report the use of anakinra to treat a case of a 64-year-old man diagnosed with haemophagocytic lymphohistiocytosis (HLH) with neurological involvement. After the administration of intravenous pulse corticosteroid therapy, immunoglobulin and anakinra the patient showed neurological recovery. However, the recovery was complicated by the perforation of a pre-existing bowel diverticulum. The effect of anakinra on bowel inflammation has not yet been clearly established. It can potentially augment bowel inflammation and contribute to the risk of bowel perforation associated with the concomitant use of corticosteroids.
Anakinra can potentially augment bowel inflammation.The concomitant use of anakinra and corticosteroids may increase the risk of bowel perforation.Use of anakinra and corticosteroids in patients with pre-existing gastrointestinal diseases requires vigilant observation for abdominal symptoms.
我们报告了使用阿那白滞素治疗一名64岁被诊断为伴有神经系统受累的噬血细胞性淋巴组织细胞增生症（HLH）的男性患者的情况。在给予静脉脉冲皮质类固醇治疗、免疫球蛋白和阿那白滞素后，患者出现神经功能恢复。然而，恢复过程因先前存在的肠道憩室穿孔而变得复杂。阿那白滞素对肠道炎症的影响尚未明确确立。它可能会加剧肠道炎症，并增加与同时使用皮质类固醇相关的肠道穿孔风险。
阿那白滞素可能会加剧肠道炎症。阿那白滞素与皮质类固醇同时使用可能会增加肠道穿孔的风险。在已有胃肠道疾病的患者中使用阿那白滞素和皮质类固醇需要密切观察腹部症状。
