Yu Zhiwei, Yu Yaocheng, Wan Yi, Fan Jing, Meng Huimin, Li Songpeng, Wang Yidi, Wang Ting, Ling Rui
Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Department of Heaepartment of Health Services, Health Service Training Base, Fourth Military Medical University, Xi'an, China.
Ann Transl Med. 2021 Oct;9(20):1567. doi: 10.21037/atm-21-4928.
Exploring the relationship between adult iodine intake level and thyroid disease in Shaanxi area is of great significance for adult scientific iodine supplement and individual iodine supplement strategy. At present, the relationship between iodine and incidence of thyroid disease has not been determined.
This study was based on the clinical data of 1,159 patients from the Shaanxi Province aged over 18 years and diagnosed with thyroid-related diseases who were admitted to the Xijing Hospital from 2016 to 2020, and 182 provincial healthy volunteers aged over 18 years who agreed and signed informed consent for physical examination in 2020. The chi-square test and nonparametric test were used to investigate the relationship between iodine intake level and thyroid disease.
(I) A total of 1,341 patients were enrolled and observed in this study. The median urinary iodine (MUI) was 233.20 μg/L. Compared with the control, group participants the urine iodine (UI) of those with hyperthyroidism, Hashimoto's thyroiditis (HT), papillary thyroid cancer (PTC), and benign nodules was significantly different (P<0.05). (II) The incidence of PTC was higher in women with excessive iodine intake and people aged ≥45 years (P<0.05). (III) There was no significant difference in urinary iodine (UI), age, gender, and other factors between benign nodules and PTC (P>0.05).
The iodine intake level of adults in Shaanxi is high, which is related to hyperthyroidism, HT, benign nodules, thyroid cancer, and other diseases. There were 3 factors, including excessive iodine intake, age ≥45 years, and female gender, found to be associated with the development of PTC.
探究陕西地区成人碘摄入量与甲状腺疾病之间的关系，对于成人科学补碘及个体化补碘策略具有重要意义。目前，碘与甲状腺疾病发病率之间的关系尚未明确。
本研究基于2016年至2020年在西京医院收治的1159例年龄超过18岁且诊断为甲状腺相关疾病的陕西省患者的临床资料，以及2020年182例年龄超过18岁且同意并签署知情同意书进行体检的省级健康志愿者的资料。采用卡方检验和非参数检验来研究碘摄入量水平与甲状腺疾病之间的关系。
（I）本研究共纳入并观察了1341例患者。尿碘中位数（MUI）为233.20μg/L。与对照组相比，甲状腺功能亢进症、桥本甲状腺炎（HT）、甲状腺乳头状癌（PTC）和良性结节患者的尿碘（UI）有显著差异（P<0.05）。（II）碘摄入过量的女性和年龄≥45岁的人群中PTC的发病率较高（P<0.05）。（III）良性结节和PTC之间在尿碘（UI）、年龄、性别及其他因素方面无显著差异（P>0.05）。
陕西地区成人碘摄入量较高，这与甲状腺功能亢进症、HT、良性结节、甲状腺癌等疾病有关。发现碘摄入过量、年龄≥45岁和女性这3个因素与PTC的发生有关。
