Sun Ying, Zhao Lei, Teng Di, Shi Xiaoguang, Li Yongze, Shan Zhongyan, Teng Weiping
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Shenyang, Liaoning, P. R. China.
Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, P. R. China.
J Clin Endocrinol Metab. 2022 Mar 24;107(4):e1631-e1642. doi: 10.1210/clinem/dgab831.
Metabolic disorders and cardiovascular disease (CVD) threaten human health. Many studies have assessed the phenomenon of metabolic disorders and CVD in patients with diabetes. However, in euglycemic individuals, the relationships between glucose regulation, metabolism, and CVD remain unclear.
This work aimed to explore the associations between postprandial glucose dips, metabolic disorders, and CVD risk.
We analyzed data from the Thyroid disorders, Iodine status and Diabetes Epidemiological survey (TIDE study), which included 38 878 euglycemic individuals from all 31 provinces of mainland China. The prevalence of metabolic disorders and their related components and CVD risk were calculated according to postprandial glucose dips. Logistic regression models of quartiles of postprandial glucose dips were used to further explore whether the prevalence of these disorders was associated with postprandial glucose dips.
Odds ratios for the fourth vs the first quartile of glucose dips were 0.59 (95% CI, 0.55-0.63) (P < .001) for metabolic disorders, 0.48 (95% CI 0.44-0.53) (P < .001) for metabolic syndrome (MetS), and 0.54 (95% CI, 0.50-0.59) (P < .001) for hyperuricemia. The odds ratio of a 10-year CVD risk greater than 20% for the fourth vs the first glucose dip quartile was 0.67 (95% CI, 0.52-0.85) (P < .001). Models adjusted for body mass index yielded similar results.
Postprandial glucose dips are associated with metabolic disorders, MetS and its related component diseases, and CVD risk. Glucose dips may be a marker of underlying metabolic abnormalities.
代谢紊乱和心血管疾病（CVD）威胁着人类健康。许多研究评估了糖尿病患者的代谢紊乱和CVD现象。然而，在血糖正常的个体中，血糖调节、代谢与CVD之间的关系仍不明确。
本研究旨在探讨餐后血糖下降、代谢紊乱和CVD风险之间的关联。
我们分析了甲状腺疾病、碘状态与糖尿病流行病学调查（TIDE研究）的数据，该研究纳入了中国大陆31个省份的38878名血糖正常的个体。根据餐后血糖下降情况计算代谢紊乱及其相关组分的患病率以及CVD风险。采用餐后血糖下降四分位数的逻辑回归模型进一步探讨这些疾病的患病率是否与餐后血糖下降有关。
血糖下降第四四分位数与第一四分位数相比，代谢紊乱的比值比为0.59（95%CI，0.55 - 0.63）（P <.001），代谢综合征（MetS）为0.48（95%CI 0.44 - 0.53）（P <.001），高尿酸血症为0.54（95%CI，0.50 - 0.59）（P <.001）。血糖下降第四四分位数与第一四分位数相比，10年CVD风险大于20%的比值比为0.67（95%CI，0.52 - 0.85）（P <.001）。调整体重指数后的模型得出了相似的结果。
餐后血糖下降与代谢紊乱、MetS及其相关组分疾病以及CVD风险相关。血糖下降可能是潜在代谢异常的一个标志物。
