Gibas Z, Becher R, Sandberg A A
Cancer Genet Cytogenet. 1983 Nov;10(3):241-53. doi: 10.1016/0165-4608(83)90052-3.
A comprehensive cytogenetic analysis has been performed in a case of erythroleukemia (EL), M6 in the FAB classification. A bone marrow sample was shown to be characterized by an unusually high degree of polyploidy with the presence of a dominating hypotetraploid clone. G-banding analysis revealed extensive structural rearrangements involving chromosomes #1,#3,#12,#16,#17, and #21. The SCE frequency was higher in the cells of the dominant clone when compared to that of near-diploid, presumably nonmalignant cells. Cell cycle analysis revealed that the hypotetraploid cells progressed through the cell cycle much slower than did the near-diploid cells.
对一例红白血病（FAB分类为M6）进行了全面的细胞遗传学分析。骨髓样本显示出异常高程度的多倍体特征，存在一个占主导地位的亚四倍体克隆。G显带分析显示涉及1号、3号、12号、16号、17号和21号染色体的广泛结构重排。与近二倍体、推测为非恶性细胞相比，优势克隆细胞中的姐妹染色单体交换频率更高。细胞周期分析显示，亚四倍体细胞通过细胞周期的速度比近二倍体细胞慢得多。
