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ZNF76 预测人类卵巢癌的预后和对铂类化疗的反应。

ZNF76 predicts prognosis and response to platinum chemotherapy in human ovarian cancer.

机构信息

Department of Gynaecology, Affiliated Xing Tai People Hospital of Hebei Medial University 399 Shunde Road, Xingtai 054001, China.

Department of Clinical laboratory, Affiliated Xingtai People Hospital of Hebei Medial University, 399 Shunde Road, Xingtai 054001, China.

出版信息

Biosci Rep. 2021 Dec 22;41(12). doi: 10.1042/BSR20212026.

DOI:10.1042/BSR20212026
PMID:34793589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8661506/
Abstract

Ovarian cancer (OV) is the most lethal gynecologic malignancy. One major reason of the high mortality of the disease is due to platinum-based chemotherapy resistance. Increasing evidence reveal the important biological functions and clinical significance of zinc finger proteins (ZNFs) in OV. In the present study, the relationship between the zinc finger protein 76 (ZNF76) and clinical outcome and platinum resistance in patients with OV was explored. We further analyzed ZNF76 expression via multiple gene expression databases and identified its functional networks using cBioPortal. RT-qPCR and IHC assay shown that the ZNF76 mRNA and protein expression were significantly lower in OV tumor than that in normal ovary tissues. A strong relationship between ZNF76 expression and platinum resistance was determined in patients with OV. The low expression of ZNF76 was associated with worse survival in OV. Multivariable analysis showed that the low expression of ZNF76 was an independent factor predicting poor outcome in OV. The prognosis value of ZNF76 in pan-cancer was validated from multiple cohorts using the PrognoScan database and GEPIA 2. A gene-clinical nomogram was constructed by multivariate cox regression analysis, combined with clinical characterization and ZNF76 expression in TCGA. Functional network analysis suggested that ZNF76 was involved in several biology progressions which associated with OV. Ten hub genes (CDC5L, DHX16, SNRPC, LSM2, CUL7, PFDN6, VARS, HSD17B8, PPIL1, and RGL2) were identified as positively associated with the expression of ZNF76 in OV. In conclusion, ZNF76 may serve as a promising prognostic-related biomarker and predict the response to platinum in OV patients.

摘要

卵巢癌（OV）是最致命的妇科恶性肿瘤。导致该疾病死亡率高的一个主要原因是铂类化疗耐药。越来越多的证据表明锌指蛋白（ZNFs）在 OV 中具有重要的生物学功能和临床意义。在本研究中，探讨了锌指蛋白 76（ZNF76）与卵巢癌患者临床结局和铂类耐药之间的关系。我们进一步通过多个基因表达数据库分析 ZNF76 的表达，并使用 cBioPortal 鉴定其功能网络。RT-qPCR 和 IHC 检测结果显示，OV 肿瘤组织中 ZNF76 mRNA 和蛋白表达明显低于正常卵巢组织。在卵巢癌患者中，ZNF76 表达与铂类耐药之间存在很强的相关性。ZNF76 低表达与 OV 患者的生存不良密切相关。多变量分析显示，ZNF76 低表达是预测 OV 不良预后的独立因素。使用 PrognoScan 数据库和 GEPIA2 从多个队列中验证了 ZNF76 在泛癌中的预后价值。通过多变量 Cox 回归分析，结合 TCGA 中的临床特征和 ZNF76 表达，构建了基因-临床列线图。功能网络分析表明，ZNF76 参与了与 OV 相关的几个生物学进程。鉴定出 10 个与 ZNF76 在 OV 中表达呈正相关的 hub 基因（CDC5L、DHX16、SNRPC、LSM2、CUL7、PFDN6、VARS、HSD17B8、PPIL1 和 RGL2）。总之，ZNF76 可能作为一种有前途的预后相关生物标志物，预测卵巢癌患者对铂类的反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/8661506/a9aabaf5cb63/bsr-41-bsr20212026-g7.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/8661506/a9aabaf5cb63/bsr-41-bsr20212026-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/8661506/51b9d6c80706/bsr-41-bsr20212026-g1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/8661506/a9aabaf5cb63/bsr-41-bsr20212026-g7.jpg

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本文引用的文献

1
Therapy Resistance in Cancers: Phenotypic, Metabolic, Epigenetic and Tumour Microenvironmental Perspectives.癌症的治疗抵抗：表型、代谢、表观遗传和肿瘤微环境的观点。
Anticancer Agents Med Chem. 2020;20(18):2190-2206. doi: 10.2174/1871520620999200730161829.
2
High expression of ZNF93 promotes proliferation and migration of ovarian cancer cells and relates to poor prognosis.ZNF93的高表达促进卵巢癌细胞的增殖和迁移，并与不良预后相关。
Int J Clin Exp Pathol. 2020 May 1;13(5):944-953. eCollection 2020.
3
Visualizing and interpreting cancer genomics data via the Xena platform.
eGastroenterology. 2024 Apr 10;2(2):e100001. doi: 10.1136/egastro-2023-100001. eCollection 2024 Apr.
4
Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer.SIRT1对胃癌中涉及H19-糖酵解-组蛋白乳酸化的正反馈环的去乳酸化酶作用。
Oncogene. 2025 Mar;44(11):724-738. doi: 10.1038/s41388-024-03243-6. Epub 2024 Dec 11.
5
LSM2 is associated with a poor prognosis and promotes cell proliferation, migration, and invasion in skin cutaneous melanoma.LSM2 与不良预后相关，并促进皮肤黑色素瘤中的细胞增殖、迁移和侵袭。
BMC Med Genomics. 2023 Jun 13;16(1):129. doi: 10.1186/s12920-023-01564-1.
6
Leveraging various extracellular matrix levels to assess prognosis and sensitivity to immunotherapy in patients with ovarian cancer.利用多种细胞外基质水平评估卵巢癌患者的预后及对免疫治疗的敏感性。
Front Oncol. 2023 May 9;13:1163695. doi: 10.3389/fonc.2023.1163695. eCollection 2023.
7
Significance of Spliceosome-Related Genes in the Prediction of Prognosis and Treatment Strategies for Lung Adenocarcinoma.剪接体相关基因在肺腺癌预后和治疗策略预测中的意义。
Biomed Res Int. 2022 Nov 4;2022:1753563. doi: 10.1155/2022/1753563. eCollection 2022.
通过Xena平台可视化和解读癌症基因组学数据。
Nat Biotechnol. 2020 Jun;38(6):675-678. doi: 10.1038/s41587-020-0546-8.
4
Cancer statistics, 2020.癌症统计数据，2020 年。
CA Cancer J Clin. 2020 Jan;70(1):7-30. doi: 10.3322/caac.21590. Epub 2020 Jan 8.
5
Depletion of CDC5L inhibits bladder cancer tumorigenesis.CDC5L的缺失抑制膀胱癌的肿瘤发生。
J Cancer. 2020 Jan 1;11(2):353-363. doi: 10.7150/jca.32850. eCollection 2020.
6
Identification of modules and hub genes associated with platinum-based chemotherapy resistance and treatment response in ovarian cancer by weighted gene co-expression network analysis.通过加权基因共表达网络分析鉴定与卵巢癌铂类化疗耐药及治疗反应相关的模块和枢纽基因。
Medicine (Baltimore). 2019 Nov;98(44):e17803. doi: 10.1097/MD.0000000000017803.
7
GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis.GEPIA2：一个用于大规模表达谱分析和交互式分析的增强型网络服务器。
Nucleic Acids Res. 2019 Jul 2;47(W1):W556-W560. doi: 10.1093/nar/gkz430.
8
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.STRING v11：具有增强覆盖范围的蛋白质-蛋白质相互作用网络，支持在全基因组实验数据集的功能发现。
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613. doi: 10.1093/nar/gky1131.
9
Targeting Transcription Factors for Cancer Treatment.靶向转录因子治疗癌症。
Molecules. 2018 Jun 19;23(6):1479. doi: 10.3390/molecules23061479.
10
Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by Transcriptional Regulation of Copper Homeostasis.通过转录调控铜稳态调节肿瘤对铂类抗肿瘤药物的化疗敏感性。
Int J Mol Sci. 2018 May 16;19(5):1486. doi: 10.3390/ijms19051486.