ZNF93的高表达促进卵巢癌细胞的增殖和迁移，并与不良预后相关。
High expression of ZNF93 promotes proliferation and migration of ovarian cancer cells and relates to poor prognosis.
作者信息
Cui Xiao-Xiao, Zhou Chen, Lu Huan, Han Yan-Li, Wang Feng-Mian, Fan Wei-Rong, Ren Yuan, Zhang Rong
机构信息
Anhui University of Science and Technology Huainan, P. R. China.
Department of Obstetrics and Gynecology, Health Sciences Affiliated Sixth People's Hospital South Campus Shanghai, P. R. China.
出版信息
Int J Clin Exp Pathol. 2020 May 1;13(5):944-953. eCollection 2020.
Abstract
Ovarian cancer (OC) is most common type of gynecologic cancer and is frequently lethal. It is important to determine the pathologic mechanisms underlying OC. ZNF93 is a member of the zinc finger protein family. Abnormal expression of ZNF93 has been observed in various tumor cells. However, its clinical significance and biologic function in ovarian cancer remain unclear. In the present study, we established that ZNF93 expression was highly up-regulated in OC samples and was closely correlated with clinical stage, indicating poor prognosis. We then established that ZNF93 promoted OC cell proliferation and migration. The results of our study may provide insight into the use of ZNF93 as a marker of clinical outcome and as a potential therapeutic target in OC.
摘要
卵巢癌（OC）是最常见的妇科癌症类型，且往往具有致命性。确定卵巢癌潜在的病理机制很重要。ZNF93是锌指蛋白家族的一员。在各种肿瘤细胞中均观察到ZNF93的异常表达。然而，其在卵巢癌中的临床意义和生物学功能仍不清楚。在本研究中，我们发现ZNF93在卵巢癌样本中的表达显著上调，且与临床分期密切相关，提示预后不良。随后我们证实ZNF93可促进卵巢癌细胞的增殖和迁移。我们的研究结果可能为将ZNF93用作卵巢癌临床预后标志物及潜在治疗靶点提供依据。
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