Tao Yuan-Ming, Bu Chong-Yang, Zou Li-Hua, Hu Yue-Li, Zheng Zhao-Juan, Ouyang Jia
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing, 210037, People's Republic of China.
College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, People's Republic of China.
Biotechnol Biofuels. 2021 Nov 18;14(1):216. doi: 10.1186/s13068-021-02067-w.
1,2-Propanediol is an important building block as a component used in the manufacture of unsaturated polyester resin, antifreeze, biofuel, nonionic detergent, etc. Commercial production of 1,2-propanediol through microbial biosynthesis is limited by low efficiency, and chemical production of 1,2-propanediol requires petrochemically derived routes involving wasteful power consumption and high pollution emissions. With the development of various strategies based on metabolic engineering, a series of obstacles are expected to be overcome. This review provides an extensive overview of the progress in the microbial production of 1,2-propanediol, particularly the different micro-organisms used for 1,2-propanediol biosynthesis and microbial production pathways. In addition, outstanding challenges associated with microbial biosynthesis and feasible metabolic engineering strategies, as well as perspectives on the future microbial production of 1,2-propanediol, are discussed.
1,2-丙二醇是一种重要的基础原料，用作制造不饱和聚酯树脂、防冻剂、生物燃料、非离子洗涤剂等的成分。通过微生物生物合成商业生产1,2-丙二醇受到效率低下的限制，而1,2-丙二醇的化学生产需要石化衍生路线，涉及能源消耗大且污染排放高。随着基于代谢工程的各种策略的发展，一系列障碍有望被克服。本文综述了1,2-丙二醇微生物生产的进展，特别是用于1,2-丙二醇生物合成的不同微生物和微生物生产途径。此外，还讨论了与微生物生物合成相关的突出挑战、可行的代谢工程策略以及1,2-丙二醇未来微生物生产的前景。
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