Department of Microbiology, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India.
Department of Microbiology, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India.
Biotechnol Adv. 2009 Nov-Dec;27(6):895-913. doi: 10.1016/j.biotechadv.2009.07.003. Epub 2009 Aug 4.
1,3-Propanediol, a valuable bifunctional molecule, can be produced from renewable resources using microorganisms. It has several promising properties for many synthetic reactions, particularly for polymer and cosmetic industries. By virtue of being a natural product, relevant biochemical pathways can be harnessed into fermentation processes to produce 1,3-propanediol. Various strategies for the microbial production of 1,3-propanediol are reviewed and compared in this article with their promises and constraints. Furthermore, genetic and metabolic engineering could significantly improve product yields and overcome the limitations of fermentation technology. Present review gives an overview on 1,3-propanediol production by wild and recombinant strains. It also attempts to encompass the various issues concerned in utilization of crude glycerol for 1,3-propanediol production, with particular emphasis laid on biodiesel industries. This review also summarizes the present state of strategies studied for the downstream processing and purification of biologically produced 1,3-propanediol. The future prospect of 1,3-propanediol and its potential as a major bulk chemical are discussed under the light of the current research.
1,3-丙二醇是一种有价值的双功能分子，可以利用微生物从可再生资源中生产。它具有许多有前途的性质，适用于许多合成反应，特别是在聚合物和化妆品工业中。由于它是一种天然产物，可以利用相关的生化途径将其转化为发酵过程，以生产 1,3-丙二醇。本文综述了微生物生产 1,3-丙二醇的各种策略，并比较了它们的优缺点。此外，遗传和代谢工程可以显著提高产品产量，并克服发酵技术的限制。本文综述了野生和重组菌株生产 1,3-丙二醇的研究进展，尝试涵盖了利用粗甘油生产 1,3-丙二醇的各种问题，特别强调了生物柴油工业。本文还总结了生物法生产 1,3-丙二醇的下游处理和纯化策略的研究现状。根据目前的研究，讨论了 1,3-丙二醇的未来前景及其作为主要大宗化学品的潜力。
