Fujinuma A
Department of Orthopedic Surgery, Teikyo University School of Medicine, Tokyo, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1987 Jun;61(6):667-79.
Twenty one cases of common type of osteosarcoma were investigated light and electron microscopically. Ultrastructurally, osteosarcoma could be classified into 4 types of cells, osteoblast-like, chondroblast-like, fibroblast-like and small round cell types. Another type of tumor cells, occasionally encountered in the tumor tissue, were myofibroblastic, osteoclastic and filopodial cells of subdivided groups. All of these were constituents of groups of tumor tissue, and were histopathologically manifested with osteoblastic, chondroblastic, fibroblastic and small round cell types of each predominant cell groups, respectively. However, the main tumor cells essentially consisted of osteoblast-like cell with prominent osteoid formation; hydroxyapatite with dense crystalline structure was characteristically deposited in the dense collagenous matrix. Osteoids also showed several structural varieties of matrix vesicles. These structural relationship to the osteoid were also discussed.
对21例常见类型的骨肉瘤进行了光镜和电镜研究。在超微结构上，骨肉瘤可分为4种细胞类型，即成骨细胞样、成软骨细胞样、成纤维细胞样和小圆形细胞类型。在肿瘤组织中偶尔会遇到的另一类肿瘤细胞是肌成纤维细胞、破骨细胞和细分群体的丝状伪足细胞。所有这些都是肿瘤组织群体的组成部分，并且在组织病理学上分别表现为以成骨细胞、成软骨细胞、成纤维细胞和小圆形细胞类型为主的细胞群体。然而，主要肿瘤细胞本质上由具有突出类骨质形成的成骨细胞样细胞组成；具有致密晶体结构的羟基磷灰石特征性地沉积在致密的胶原基质中。类骨质还显示出基质小泡的几种结构变体。还讨论了这些与类骨质的结构关系。
