Sluiter W, Elzenga-Claasen I, van Hemsbergen-Oomens L W, van der Voort van der Kley-van Andel A, van Dissel J T, van Furth R
Department of Infectious Diseases, University Hospital, Leiden, Holland.
J Leukoc Biol. 1987 Dec;42(6):653-8. doi: 10.1002/jlb.42.6.653.
The regulatory mechanisms that determine the course of an inflammation induced by an intraperitoneal injection of kaolin were investigated in Listeria-susceptible CBA and Listeria-resistant B10 mice. The magnitude of the granulocyte inflammatory response in the peritoneal cavity was high in B10 mice (area under the curve; AUC0-48 h: 210.9 x 10(6) granulocytes/mouse x h) and lower in CBA mice AUC0-48 h: 136.8 x 10(6) granulocytes/mouse x h), whereas the reverse was seen for the granulocyte response in the peripheral blood (AUC0-48 h: 30.5 and 80.7 x 10(6) granulocytes/mouse x h, respectively). With respect to the presence of humoral factors that affect the number of granulocytes in the circulation, sera of both mouse strains sampled 24 h after the kaolin injection had granulocytosis-inducing effect in CBA recipient mice and did not induce a response in the B10 recipient mice. This divergent sensitivity to serum factors inducing granulocytosis is consistent with the difference in the blood granulocyte response of B10 and CBA mice but does not explain the divergent inflammatory responses in the peritoneal cavity. Computer simulation showed that at least two factors must be taken into consideration to explain the differences in the inflammatory response, i.e., a factor regulating the release of granulocytes from the bone marrow and a factor governing the rate of granulocyte efflux from the site of inflammation.
在对李斯特菌敏感的CBA小鼠和对李斯特菌有抗性的B10小鼠中，研究了决定腹腔注射高岭土所诱导炎症进程的调节机制。B10小鼠腹腔内粒细胞炎症反应的强度较高（曲线下面积；AUC0 - 48小时：210.9×10⁶粒细胞/小鼠×小时），而CBA小鼠较低（AUC0 - 48小时：136.8×10⁶粒细胞/小鼠×小时），而外周血中粒细胞反应则相反（AUC0 - 48小时：分别为30.5和80.7×10⁶粒细胞/小鼠×小时）。关于影响循环中粒细胞数量的体液因子的存在，高岭土注射后24小时采集的两种小鼠品系的血清，在CBA受体小鼠中具有诱导粒细胞增多的作用，而在B10受体小鼠中未诱导出反应。这种对诱导粒细胞增多的血清因子的不同敏感性与B10和CBA小鼠血液中粒细胞反应的差异一致，但不能解释腹腔内不同的炎症反应。计算机模拟表明，至少必须考虑两个因素来解释炎症反应的差异，即调节粒细胞从骨髓释放的因子和控制粒细胞从炎症部位流出速率的因子。
