依托泊苷和环磷酰胺对氯唑西林和红霉素治疗实验性葡萄球菌感染疗效的影响。
Influence of etoposide and cyclophosphamide on the efficacy of cloxacillin and erythromycin in an experimental staphylococcal infection.
作者信息
Calame W, van der Waals R, Mattie H, van Furth R
机构信息
Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
出版信息
Antimicrob Agents Chemother. 1989 Jun;33(6):980-2. doi: 10.1128/AAC.33.6.980.
Abstract
The effect of monocytopenia and granulocytopenia on the outgrowth of Staphylococcus aureus as well as on antibiotic efficacy was studied in an experimental thigh infection in mice. Pretreatment with etoposide reduced monocyte numbers in blood to 14% and those of granulocytes to 54% at the time of infection. Monocytopenia did not affect the proliferation of bacteria in the infected thigh or the reduction of bacterial numbers after treatment with cloxacillin or erythromycin. Pretreatment with cyclophosphamide reduced monocyte numbers to 15% and granulocyte numbers to 3%. This resulted in a marked increase in the number of bacteria at the site of infection and a decrease in the efficacy of antibiotic treatment.
摘要
在小鼠大腿感染实验中，研究了单核细胞减少症和粒细胞减少症对金黄色葡萄球菌生长以及抗生素疗效的影响。用依托泊苷预处理后，感染时血液中的单核细胞数量降至14%，粒细胞数量降至54%。单核细胞减少症并不影响感染大腿中细菌的增殖，也不影响用氯唑西林或红霉素治疗后细菌数量的减少。用环磷酰胺预处理后，单核细胞数量降至15%，粒细胞数量降至3%。这导致感染部位细菌数量显著增加，抗生素治疗效果降低。
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本文引用的文献
1
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Infection. 1984 Jan-Feb;12(1):5-9. doi: 10.1007/BF01641015.
2
Method to select mice in the steady state for biological studies.用于生物学研究的稳态小鼠选择方法。
J Immunol Methods. 1985 Jan 21;76(1):135-43. doi: 10.1016/0022-1759(85)90486-7.
3
Quantitative effect of granulocytes on antibiotic treatment of experimental staphylococcal infection.粒细胞对实验性葡萄球菌感染抗生素治疗的定量影响。
Antimicrob Agents Chemother. 1987 Jun;31(6):930-4. doi: 10.1128/AAC.31.6.930.
4
Antibiotic therapy of infections due to Pseudomonas aeruginosa in normal and granulocytopenic mice: comparison of murine and human pharmacokinetics.铜绿假单胞菌感染在正常小鼠和粒细胞缺乏小鼠中的抗生素治疗：鼠类与人药代动力学的比较
J Infect Dis. 1986 Jan;153(1):90-7. doi: 10.1093/infdis/153.1.90.
5
Regulation of granulocyte responses in the blood and peritoneal cavity of CBA and B10 mice during an acute inflammation.急性炎症期间CBA和B10小鼠血液和腹腔中粒细胞反应的调节
J Leukoc Biol. 1987 Dec;42(6):653-8. doi: 10.1002/jlb.42.6.653.
6
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