Calame W, van der Waals R, Mattie H, van Furth R
Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
Antimicrob Agents Chemother. 1989 Jun;33(6):980-2. doi: 10.1128/AAC.33.6.980.
The effect of monocytopenia and granulocytopenia on the outgrowth of Staphylococcus aureus as well as on antibiotic efficacy was studied in an experimental thigh infection in mice. Pretreatment with etoposide reduced monocyte numbers in blood to 14% and those of granulocytes to 54% at the time of infection. Monocytopenia did not affect the proliferation of bacteria in the infected thigh or the reduction of bacterial numbers after treatment with cloxacillin or erythromycin. Pretreatment with cyclophosphamide reduced monocyte numbers to 15% and granulocyte numbers to 3%. This resulted in a marked increase in the number of bacteria at the site of infection and a decrease in the efficacy of antibiotic treatment.
在小鼠大腿感染实验中，研究了单核细胞减少症和粒细胞减少症对金黄色葡萄球菌生长以及抗生素疗效的影响。用依托泊苷预处理后，感染时血液中的单核细胞数量降至14%，粒细胞数量降至54%。单核细胞减少症并不影响感染大腿中细菌的增殖，也不影响用氯唑西林或红霉素治疗后细菌数量的减少。用环磷酰胺预处理后，单核细胞数量降至15%，粒细胞数量降至3%。这导致感染部位细菌数量显著增加，抗生素治疗效果降低。
