Singh Arminder, Everest Stephanie, Nguyen Lam, Hailemichael Teshome
Internal Medicine, Cape Fear Valley Medical Center, Fayetteville, USA.
School of Medicine, Campbell University School of Osteopathic Medicine, Lillington, USA.
Cureus. 2021 Oct 12;13(10):e18727. doi: 10.7759/cureus.18727. eCollection 2021 Oct.
Renal cell carcinoma (RCC) is known to cause abdominal pain, hematuria, flank pain, fevers, night sweats, and weight loss, but its association with paraneoplastic syndromes such as intractable cough is rare. Here, we present the case of an 86-year-old female who presented with a persistent dry cough for two months. Computed tomography (CT) of the abdomen and pelvis with contrast revealed large left renal mass consistent with renal cell carcinoma spreading through Gerota's fascia and metastatic to regional lymph nodes. Biopsy of the mass tested positive for renal cell carcinoma markers. Ultimately, the patient was deemed a nonsurgical candidate and treated with immunotherapy. In this case study, we discuss the rare but important clinical findings leading to the possible diagnosis of paraneoplastic cough secondary to RCC.
肾细胞癌（RCC）已知会引起腹痛、血尿、侧腹痛、发热、盗汗和体重减轻，但其与诸如顽固性咳嗽等副肿瘤综合征的关联较为罕见。在此，我们报告一例86岁女性患者，她持续干咳两个月。腹部和盆腔增强计算机断层扫描（CT）显示左肾有一个大肿块，符合肾细胞癌，肿瘤已穿过肾周筋膜并转移至区域淋巴结。肿块活检肾细胞癌标志物检测呈阳性。最终，该患者被判定为非手术候选者并接受免疫治疗。在本病例研究中，我们讨论了导致可能诊断为RCC继发副肿瘤性咳嗽的罕见但重要的临床发现。
