Ernster V L, Wrensch M R, Petrakis N L, King E B, Miike R, Murai J, Goodson W H, Siiteri P K
Department of Epidemiology and International Health, School of Medicine, University of California, San Francisco 94143.
J Natl Cancer Inst. 1987 Nov;79(5):949-60.
Design, methods, and study population of a long-term multidisciplinary investigation of benign and malignant breast disease were reported. This initial report focused on the relation of menstrual, reproductive, and other factors to serum and breast fluid estrogen measures [estradiol (E2), estrone (E1), percent free estrogen, and sex hormone binding globulin] among control women. After adjustment for the factors found to be related to the various estrogen measures, estrogen levels in women with benign and malignant disease were compared to those of controls. Findings were as follows: a) little evidence of any relation of most breast cancer risk factors with the various serum estrogen parameters studied; b) differences in breast fluid estrogen levels that may be relevant to the protective effect of parity on breast cancer risk; c) markedly higher levels of E2 and E1 in breast fluid than in serum and no evidence of a correlation of serum with breast fluid measures; d) no support for the hypothesis that breast cancer patients have higher serum percent free E2 than controls or women with benign breast disease; and e) higher breast fluid E2 and E1 levels in women with biopsied benign breast disease than in controls.
报告了一项针对良性和恶性乳腺疾病的长期多学科研究的设计、方法和研究人群。这份初步报告聚焦于月经、生殖及其他因素与对照组女性血清和乳腺液雌激素指标[雌二醇（E2）、雌酮（E1）、游离雌激素百分比及性激素结合球蛋白]之间的关系。在对发现与各种雌激素指标相关的因素进行调整后，将患有良性和恶性疾病的女性的雌激素水平与对照组进行了比较。结果如下：a）大多数乳腺癌风险因素与所研究的各种血清雌激素参数之间几乎没有关联的证据；b）乳腺液雌激素水平的差异可能与生育对乳腺癌风险的保护作用有关；c）乳腺液中E2和E1的水平明显高于血清，且没有证据表明血清与乳腺液指标之间存在相关性；d）不支持乳腺癌患者血清游离E2百分比高于对照组或患有良性乳腺疾病女性的假设；e）经活检患有良性乳腺疾病的女性的乳腺液E2和E1水平高于对照组。
