Abdel-Khalek Amr Adel, Al-Quraishy Saleh, Abdel-Gaber Rewaida
Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt.
Department of Zoology, College of Science, King Saud University, P.O. Box 145111, Riyadh, Saudi Arabia.
Bull Environ Contam Toxicol. 2022 Apr;108(4):663-671. doi: 10.1007/s00128-021-03406-1. Epub 2021 Nov 19.
This study aimed to investigate the testicular function of Mugil cephalus that inhabit Wadi El-Rayan lakes. Testes of fish inhabiting the upper lake (site 2) and the lower lake (site 3) of Wadi El-Rayan showed significant decreases in gonadosomatic index, high accumulation levels of six metals, and eight organochlorine pesticide residues. Compared to reference fish, high percentages of histological alterations as testicular degeneration, germ cell reduction, testicular inflammation, vacuolization, and loss of tubular arrangement were observed in sites 2 and 3. Moreover, endocrine disruption signs were recorded based on the percentage of ovotestis appearance and the ovotestis severity index values. The maximum defective testicular antioxidant mechanisms were recorded in site 3 as indicated by sharp decreases in catalase, superoxide dismutase, glutathione reduced levels, and high thiobarbituric acid reactive substances. Finally, long-term exposure to Wadi El-Rayan water may impair the reproductive health of fish via testicular oxidative damage and endocrine disruption.
本研究旨在调查栖息于瓦迪雷扬湖的尖吻鲈的睾丸功能。栖息在瓦迪雷扬湖上游湖泊（2号地点）和下游湖泊（3号地点）的鱼类的睾丸显示，其性腺指数显著下降，六种金属和八种有机氯农药残留的积累水平较高。与对照鱼相比，在2号和3号地点观察到高比例的组织学改变，如睾丸退化、生殖细胞减少、睾丸炎症、空泡化和管状排列丧失。此外，根据卵睾出现的百分比和卵睾严重程度指数值记录了内分泌干扰迹象。3号地点记录到最大程度的睾丸抗氧化机制缺陷，表现为过氧化氢酶、超氧化物歧化酶、还原型谷胱甘肽水平急剧下降，以及硫代巴比妥酸反应性物质含量升高。最后，长期暴露于瓦迪雷扬湖的水体可能通过睾丸氧化损伤和内分泌干扰损害鱼类的生殖健康。
