Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, P. R. China.
Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun 130033, P. R. China.
ACS Appl Mater Interfaces. 2021 Dec 8;13(48):56719-56724. doi: 10.1021/acsami.1c14781. Epub 2021 Nov 19.
Immunoregulation represents a booming field of biomaterial design. The unique physical and chemical properties of biomaterials offer tremendous opportunities for development. Each of their parameters exerts immunogenic effects at the immune system, cellular, and molecular levels. Herein, the perspective summarizes the interaction of biomaterials with immune cells and the underlying mechanisms to control immunoregulation in a top-down manner, providing solid inspiration for biomedical applications of immunologically effective biomaterials.
免疫调节代表了生物材料设计的一个蓬勃发展的领域。生物材料独特的物理和化学性质为其发展提供了巨大的机会。它们的每个参数都在免疫系统、细胞和分子水平上产生免疫原性效应。本文从综述的角度总结了生物材料与免疫细胞的相互作用及其内在的调控机制，为免疫有效生物材料的生物医学应用提供了坚实的启示。
