Li Jiacheng, Xie Jiatong, Wang Yaming, Li Xixian, Yang Liqun, Zhao Muxin, Chen Chaoxian
Department of Plastic Surgery, The Second Affiliated Hospital, Dalian Medical University, Dalian 116041, China.
The Second Clinical College, Dalian Medical University, Dalian 116044, China.
Bioengineering (Basel). 2024 Oct 12;11(10):1017. doi: 10.3390/bioengineering11101017.
Wound healing is a complex and precisely regulated process that encompasses multiple stages, including inflammation, anti-inflammation, and tissue repair. It involves various cells and signaling molecules, with macrophages demonstrating a significant degree of plasticity and playing a crucial regulatory role at different stages. In recent years, the use of biomaterials, which include both natural and synthetic polymers or macromolecules, has proliferated for the purpose of enhancing wound healing. This review summarizes how these diverse biomaterials promote wound healing by modulating macrophage behavior and examines the broader implications of these modulations. Additionally, we discuss the limitations associated with the clinical application of immunomodulatory biomaterials and propose potential solutions. Finally, we look towards future developments in the design of immunomodulatory biomaterials intended to enhance wound healing.
伤口愈合是一个复杂且精确调控的过程，涵盖多个阶段，包括炎症、抗炎和组织修复。它涉及多种细胞和信号分子，其中巨噬细胞表现出高度的可塑性，并在不同阶段发挥关键的调节作用。近年来，包括天然和合成聚合物或大分子在内的生物材料的使用激增，目的是促进伤口愈合。本综述总结了这些不同的生物材料如何通过调节巨噬细胞行为来促进伤口愈合，并探讨了这些调节的更广泛影响。此外，我们讨论了免疫调节生物材料临床应用的相关局限性，并提出了潜在的解决方案。最后，我们展望旨在促进伤口愈合的免疫调节生物材料设计的未来发展。
