Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Guangdong Cardiovascular Institute, Guangzhou, China.
Invest Ophthalmol Vis Sci. 2021 Nov 1;62(14):19. doi: 10.1167/iovs.62.14.19.
To examine the association between adiposity by differing measures and incident cataract and identify important factors contributing to the association.
Our analysis included 153,139 adults from the UK Biobank, aged 40 to 70 years at baseline (2006-2010). Cataract was ascertained using hospital inpatient, and self-reported data until the early of 2021. Anthropometric measures, body fat percentage, and glycosylated hemoglobin (HbA1c) were measured at baseline.
During a median follow-up of 10.9 years, 15,255 cases of incident cataract were documented. HbA1c was an important contributor to the association between obesity and incident cataract. Obesity; defined by body mass index was associated with an increased risk of cataract (hazard ratio [HR], 1.21 95% confidence interval [CI], 1.16-1.26), and this association was attenuated but remained significant after additional adjustment for HbA1c (HR, 1.05; 95% CI, 1.00-1.10). Similar results were observed for obesity defined by waist circumference or waist-to-hip ratio. Obesity defined by fat percentage was associated with an increased risk of cataract before but not after adjustment for covariates. The association between obesity defined by body mass index and incident cataract was positively significant in individuals with normal HbA1c (HR, 1.07; 95% CI, 1.02-1.13), but inversely significant in those with prediabetes (HR, 0.80; 95% CI, 0.67-0.96) or diabetes (HR, 0.74; 95% CI, 0.61-0.89).
Anthropometric measurements are more predictive of cataract than bioelectrical impedance measures. Diabetes plays an important role in the association between obesity and incident cataract.
研究不同肥胖指标与白内障发病的相关性，并确定导致这种相关性的重要因素。
我们的分析包括来自英国生物库的 153139 名 40 至 70 岁的成年人，他们在 2006 年至 2010 年基线时接受了检查。白内障的确诊依据是住院患者和自我报告的数据，直至 2021 年初。在基线时测量了人体测量指标、体脂肪百分比和糖化血红蛋白（HbA1c）。
在中位随访 10.9 年期间，记录了 15255 例白内障发病病例。HbA1c 是肥胖与白内障发病相关性的重要因素。体重指数定义的肥胖与白内障发病风险增加相关（危险比 [HR]，1.21；95%置信区间 [CI]，1.16-1.26），而在进一步调整 HbA1c 后，这种相关性减弱但仍然显著（HR，1.05；95% CI，1.00-1.10）。腰围或腰臀比定义的肥胖和体脂肪百分比定义的肥胖也观察到类似的结果。在调整协变量之前，体脂肪百分比定义的肥胖与白内障发病风险增加相关，但在调整后则无相关性。体重指数定义的肥胖与白内障发病的相关性在 HbA1c 正常的个体中呈正显著（HR，1.07；95% CI，1.02-1.13），但在糖尿病前期（HR，0.80；95% CI，0.67-0.96）或糖尿病（HR，0.74；95% CI，0.61-0.89）患者中则呈负显著。
人体测量指标比生物电阻抗测量更能预测白内障。糖尿病在肥胖与白内障发病的相关性中起着重要作用。
