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利用射线追踪模拟研究公共环境中使用 UV-C LEDs 对 SARS-CoV-2 的灭活作用。

Investigation of SARS-CoV-2 inactivation using UV-C LEDs in public environments via ray-tracing simulation.

机构信息

A*STAR Institute of High Performance Computing, Electronics and Photonics, 1 Fusionopolis Way, #16-16, Connexis, 138632, Singapore.

A*STAR Singapore Institute of Manufacturing Technology, 2 Fusionopolis Way, #08-04, Innovis, 138634, Singapore.

出版信息

Sci Rep. 2021 Nov 19;11(1):22612. doi: 10.1038/s41598-021-02156-8.

DOI:10.1038/s41598-021-02156-8
PMID:34799671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8605003/
Abstract

This paper proposes an investigating SARS-CoV-2 inactivation on surfaces with UV-C LED irradiation using our in-house-developed ray-tracing simulator. The results are benchmarked with experiments and Zemax OpticStudio commercial software simulation to demonstrate our simulator's easy accessibility and high reliability. The tool can input the radiant profile of the flexible LED source and accurately yield the irradiance distribution emitted from an LED-based system in 3D environments. The UV-C operating space can be divided into the safe, buffer, and germicidal zones for setting up a UV-C LED system. Based on the published measurement data, the level of SARS-CoV-2 inactivation has been defined as a function of UV-C irradiation. A realistic case of public space, i.e., a food court in Singapore, has been numerically investigated to demonstrate the relative impact of environmental UV-C attenuation on the SARS-CoV-2 inactivation. We optimise a specific UV-C LED germicidal system and its corresponding exposure time according to the simulation results. These ray-tracing-based simulations provide a useful guideline for safe deployment and efficient design for germicidal UV-C LED technology.

摘要

本文提出了一种使用我们内部开发的光线追踪模拟器研究 SARS-CoV-2 在表面上的紫外线-C（UV-C）LED 照射灭活的方法。结果与实验和 Zemax OpticStudio 商业软件模拟进行了基准测试，以证明我们模拟器的易用性和高可靠性。该工具可以输入灵活 LED 源的辐射分布，并在 3D 环境中准确地得出基于 LED 的系统发出的辐照度分布。UV-C 工作空间可以划分为安全区、缓冲区和杀菌区，以建立 UV-C LED 系统。基于已发表的测量数据，将 SARS-CoV-2 的灭活水平定义为 UV-C 照射的函数。还对新加坡一个公共空间，即一个美食广场，进行了数值研究，以展示环境 UV-C 衰减对 SARS-CoV-2 灭活的相对影响。我们根据模拟结果优化了特定的 UV-C LED 杀菌系统及其相应的暴露时间。这些基于光线追踪的模拟为安全部署和高效设计杀菌 UV-C LED 技术提供了有用的指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/d36055edc88d/41598_2021_2156_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/9b78e95ac521/41598_2021_2156_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/1fc5d85029fe/41598_2021_2156_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/3c5bc80d8611/41598_2021_2156_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/e7ab9863a1cf/41598_2021_2156_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/cff23f102c62/41598_2021_2156_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/9b9b91b43420/41598_2021_2156_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/73418145056f/41598_2021_2156_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/d36055edc88d/41598_2021_2156_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/9b78e95ac521/41598_2021_2156_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/1fc5d85029fe/41598_2021_2156_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/3c5bc80d8611/41598_2021_2156_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/e7ab9863a1cf/41598_2021_2156_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/cff23f102c62/41598_2021_2156_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/9b9b91b43420/41598_2021_2156_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/73418145056f/41598_2021_2156_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f284/8605003/d36055edc88d/41598_2021_2156_Fig8_HTML.jpg

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