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利用基于 CFD 的室内消毒模拟估算气溶胶 SARS-CoV-2 对 254nm 照射的紫外线敏感性。

Estimation of the UV susceptibility of aerosolized SARS-CoV-2 to 254 nm irradiation using CFD-based room disinfection simulations.

机构信息

Signify, High Tech Campus 7, 5656AE, Eindhoven, The Netherlands.

出版信息

Sci Rep. 2024 Jul 10;14(1):15963. doi: 10.1038/s41598-024-63472-3.

DOI:10.1038/s41598-024-63472-3
PMID:38987323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11237116/
Abstract

The recent COVID-19 pandemic has raised interest in efficient air disinfection solutions. The application of germicidal ultraviolet (GUV) irradiation is an excellent contender to prevent airborne transmission of COVID-19, as well as other existing and future infectious airborne diseases. While GUV has already been proven effective in inactivating SARS-CoV-2, quantitative data on UV susceptibility and dose requirements, needed to predict and optimize the performance of GUV solutions, is still limited. In this study, the UV susceptibility of aerosolized SARS-CoV-2 to 254 nm ultraviolet (UV) irradiation is investigated. This is done by employing 3D computational fluid dynamics based simulations of SARS-CoV-2 inactivation in a test chamber equipped with an upper-room UV-C luminaire and comparing the results to previously published measurements performed in the same test chamber. The UV susceptibility found in this study is (0.6 ± 0.2) m/J, which is equivalent to a D dose between 3 and 6 J/m. These values are in the same range as previous estimations based on other corona viruses and inactivation data reported in literature.

摘要

最近的 COVID-19 大流行引起了人们对高效空气消毒解决方案的兴趣。杀菌紫外线 (GUV) 照射的应用是预防 COVID-19 以及其他现有和未来的空气传播传染病的绝佳选择。虽然 GUV 已被证明可有效灭活 SARS-CoV-2，但仍缺乏预测和优化 GUV 溶液性能所需的关于紫外线敏感性和剂量要求的定量数据。在这项研究中，研究了气溶胶 SARS-CoV-2 对 254nm 紫外线 (UV) 照射的紫外线敏感性。这是通过使用配备上室 UV-C 灯具的测试室中 SARS-CoV-2 灭活的基于 3D 计算流体动力学的模拟来完成的，并将结果与在相同测试室中进行的先前发表的测量结果进行比较。本研究中发现的紫外线敏感性为（0.6±0.2）m/J，相当于 3 至 6 J/m 的 D 剂量。这些值与基于其他冠状病毒的先前估计值以及文献中报告的失活动力学数据处于同一范围。

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