Zabow Gary, Dodd Stephen, Koretsky Alan
Applied Physics Division, National Institute of Standards and Technology, Boulder, CO 80305, USA.
Laboratory of Functional and Molecular Imaging, NINDS, National Institutes of Health, Bethesda, MD 20892, USA.
J Magn Reson. 2021 Dec;333:107100. doi: 10.1016/j.jmr.2021.107100. Epub 2021 Oct 30.
Meander-line, or zig-zag, MRI surface coils theoretically promise spatially uniform fields with optimal field localization close to the coil. In reality, they suffer poorer than expected field localizations and acquired images are often highly inhomogeneous, plagued by repeating stripe-like signal-loss artifacts. We show that both these detrimental effects arise from coil design based on the same invalid approximation in the underlying theory. Here, the conventional approximation is corrected, yielding a modified coil design that validates the new theory by rectifying the above problems. Specifically, an easily implementable coil correction, which amounts to the addition of a single extra turn of wire, is introduced and shown to increase signal uniformity by an order of magnitude, eliminate image artifacts, and reduce unwanted signal interference from deeper within the sample by tightening the coil field localization to close to the coil, as intended for zig-zag designs. With independent optimization of coil size and imaging depth possible, such corrected meander-lines surface coils may be well suited for large area, near-surface imaging and spectroscopy applications.
曲折线或之字形MRI表面线圈理论上有望产生空间均匀的磁场,且在靠近线圈处具有最佳的磁场定位。实际上,它们的磁场定位比预期的要差,获取的图像通常高度不均匀,常出现重复的条纹状信号丢失伪影。我们表明,这两种不利影响都源于基于基础理论中相同无效近似的线圈设计。在此,对传统近似进行了修正,得出一种改进的线圈设计,通过解决上述问题验证了新理论。具体而言,引入了一种易于实现的线圈修正方法,即增加一匝额外的导线,结果表明这可将信号均匀性提高一个数量级,消除图像伪影,并通过将线圈磁场定位收紧至靠近线圈(如同之字形设计所期望的那样)来减少来自样品更深层的不必要信号干扰。由于可以独立优化线圈尺寸和成像深度,这种经过修正的曲折线表面线圈可能非常适合大面积、近表面成像和光谱应用。