OIDx 组织胞浆菌尿抗原 EIA 检测评估。
Evaluation of OIDx Histoplasma Urinary Antigen EIA.
机构信息
Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA, 30333, USA.
Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands.
出版信息
Mycopathologia. 2022 Feb;187(1):129-131. doi: 10.1007/s11046-021-00602-9. Epub 2021 Nov 20.
A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92%, specificity of 32% and accuracy of 51%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68% of specimens tested.
一种由 Optimum Imaging Diagnostics (OIDx) 开发的用于检测尿液中组织胞浆菌抗原 (Ag) 的夹心酶免疫测定法 (EIA) 进行了评估。使用标准化的尿液样本参考面板进行验证发现，该方法的灵敏度为 92%，特异性为 32%，准确性为 51%。在这项研究中，OIDx 组织胞浆菌尿 Ag EIA 显示出很高的灵敏度，然而，在非组织胞浆菌病病例中，该 EIA 在 68%的检测标本中显示出假阳性结果。
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