Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA, 30333, USA.
Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands.
Mycopathologia. 2022 Feb;187(1):129-131. doi: 10.1007/s11046-021-00602-9. Epub 2021 Nov 20.
A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92%, specificity of 32% and accuracy of 51%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68% of specimens tested.
一种由 Optimum Imaging Diagnostics (OIDx) 开发的用于检测尿液中组织胞浆菌抗原 (Ag) 的夹心酶免疫测定法 (EIA) 进行了评估。使用标准化的尿液样本参考面板进行验证发现，该方法的灵敏度为 92%，特异性为 32%，准确性为 51%。在这项研究中，OIDx 组织胞浆菌尿 Ag EIA 显示出很高的灵敏度，然而，在非组织胞浆菌病病例中，该 EIA 在 68%的检测标本中显示出假阳性结果。
