Hunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, Central South University of Forestry and Technology, Changsha, Hunan, 410004, China.
Mol Nutr Food Res. 2022 Jan;66(2):e2100732. doi: 10.1002/mnfr.202100732. Epub 2021 Dec 6.
Cancer is a serious public health problem in the world and a major disease affecting human health. Dietary polyphenols have shown good potential in the treatment of various cancers. It is worth noting that cancer cells usually exhibit metabolic abnormalities of high glucose intake and inefficient utilization. AMPK is the key molecule in the regulation of energy metabolism and is closely related with obesity and diabetes. Recent studies indicate that AMPK also plays an important role in cancer prevention and regulating cancer-related genes and pathways, and dietary polyphenols can significantly regulate AMPK activity. In this review, the progress of dietary polyphenols preventing carcinogenesis via AMPK pathway is systemically summarized. From the viewpoint of interfering energy metabolism, the anti-cancer effects of dietary polyphenols are explained. AMPK pathway modulated by different dietary polyphenols affects pathways and target genes are summarized. Dietary polyphenols exert anti-cancer effect through the target molecules regulated by AMPK, which broadens the understanding of polyphenols anti-cancer mechanisms and provides value reference for the investigators of the novel field.
癌症是全球严重的公共卫生问题，也是影响人类健康的主要疾病之一。膳食多酚在治疗各种癌症方面显示出良好的潜力。值得注意的是，癌细胞通常表现出高葡萄糖摄取和低效利用的代谢异常。AMPK 是调节能量代谢的关键分子，与肥胖和糖尿病密切相关。最近的研究表明，AMPK 在癌症预防和调节与癌症相关的基因和途径方面也起着重要作用，膳食多酚可以显著调节 AMPK 的活性。在这篇综述中，系统地总结了膳食多酚通过 AMPK 途径预防致癌作用的研究进展。从干扰能量代谢的角度，阐述了膳食多酚的抗癌作用。总结了不同膳食多酚调节的 AMPK 通路影响的途径和靶基因。AMPK 调节的靶分子通过 AMPK 发挥抗癌作用，这拓宽了对多酚抗癌机制的理解，并为该新型领域的研究人员提供了有价值的参考。
