Laboratory of Veterinary Surgery, Clinical Veterinary Medicine, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Cookie Animal Hospital, 2-5-25 Shinonomehigashimachi, Kita-ku, Sakai-shi, Osaka 591-8041, Japan.
J Vet Med Sci. 2022 Jan 7;84(1):64-68. doi: 10.1292/jvms.21-0393. Epub 2021 Nov 22.
The standard procedure to treat oronasal fistula in dogs requires tooth extraction to close the fistula; hence, the subject would lose its tooth. In this study, trafermin was applied to four dog models with oronasal fistula to investigate the periodontal tissue regenerative effects of trafermin in the treatment without tooth extraction. A fistula was created along the palatal side of each upper canine tooth. One of the fistulae was filled with trafermin, whereas that on the contralateral side was left unfilled as a control. The results showed a significant decrease in the non-calcified periodontal tissue volume on the trafermin side after the fourth week. In addition, oronasal fistula closure was visually and histologically confirmed at the eighth week on the trafermin side of all four models.
治疗犬的口鼻瘘的标准程序需要拔牙来关闭瘘管；因此，患犬会失去牙齿。在这项研究中，将 trafermin 应用于四个具有口鼻瘘的犬模型中，以研究 trafermin 在不拔牙治疗中的牙周组织再生效果。在上颌犬齿的腭侧侧方各创建一个瘘管。一个瘘管用 trafermin 填充，而对侧的瘘管则不填充作为对照。结果显示，第四周后，trafermin 侧的非钙化牙周组织体积显著减少。此外，所有四个模型的 trafermin 侧在第八周时均通过肉眼观察和组织学确认了口鼻瘘的闭合。
