Harris J C, Bryan R A, Lucas V S, Roberts G J
Harrow and Hillingdon Healthcare NHS Trust, Eastman Dental Institute for Oral Health Care Sciences, University College London, United Kingdom.
Pediatr Dent. 2001 Sep-Oct;23(5):438-43.
The purpose of this study was to investigate dental caries, bacterial dental plaque, gingivitis and caries related oral microflora in children with predominantly autosomal recessive Dystrophic Epidermolysis Bullosa (DEB).
Thirty children with DEB from The Great Ormond Street Hospital for Children and 31 control children matched for age, gender and ethnicity were included in the study.
The main findings were: 1. A significantly greater mean dmft in the DEB children (p < 0.05). 2. A significantly greater mean plaque score for the DEB children for both the primary (p < 0.001) and permanent teeth (p < 0.02) compared with the control children. 3. A significantly greater mean gingivitis score for the DEB children for both the primary (p < 0.002) and permanent teeth (p < 0.0001) compared with the control children. 4. A significantly greater salivary total anaerobic count for the control children compared with the DEB children (p < 0.001).
The results reflect the difficulties that children with DEB have with basic oral hygiene procedures combined with slow oral clearance.
本研究旨在调查以常染色体隐性遗传性营养不良型大疱性表皮松解症（DEB）为主的儿童的龋齿、细菌性牙菌斑、牙龈炎及与龋齿相关的口腔微生物群。
本研究纳入了来自大奥蒙德街儿童医院的30名患有DEB的儿童以及31名年龄、性别和种族相匹配的对照儿童。
主要研究结果如下：1. DEB儿童的平均乳牙龋失补牙数（dmft）显著更高（p < 0.05）。2. 与对照儿童相比，DEB儿童乳牙（p < 0.001）和恒牙（p < 0.02）的平均菌斑评分显著更高。3. 与对照儿童相比，DEB儿童乳牙（p < 0.002）和恒牙（p < 0.0001）的平均牙龈炎评分显著更高。4. 与DEB儿童相比，对照儿童唾液中的总厌氧菌计数显著更高（p < 0.001）。
研究结果反映出DEB儿童在基本口腔卫生措施方面存在困难，且口腔清洁缓慢。
