Li Dongxue, Zhang Zhe, Xia Chengyu, Niu Chaoshi, Zhou Wenchao
Intelligent Pathology Institute, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Department of Neurosurgery, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Front Mol Neurosci. 2021 Nov 3;14:763610. doi: 10.3389/fnmol.2021.763610. eCollection 2021.
Glioma, especially glioblastoma, is the most common and lethal brain tumor. In line with the complicated vascularization processes and the strong intratumoral heterogeneity, tumor-associated blood vessels in glioma are regulated by multiple types of cells through a variety of molecular mechanisms. Components of the tumor microenvironment, including tumor cells and tumor-associated stromata, produce various types of molecular mediators to regulate glioma angiogenesis. As critical regulatory molecules, non-coding RNAs (ncRNAs) inside cells or secreted to the tumor microenvironment play essential roles in glioma angiogenesis. In this review, we briefly summarize recent studies about the production, delivery, and functions of ncRNAs in the tumor microenvironment, as well as the molecular mechanisms underlying the regulation of angiogenesis by ncRNAs. We also discuss the ncRNA-based therapeutic strategies in the anti-angiogenic therapy for glioma treatment.
神经胶质瘤，尤其是胶质母细胞瘤，是最常见且致命的脑肿瘤。鉴于其复杂的血管生成过程和强烈的肿瘤内异质性，神经胶质瘤中与肿瘤相关的血管受到多种类型细胞通过多种分子机制的调控。肿瘤微环境的组成部分，包括肿瘤细胞和肿瘤相关基质，会产生各种类型的分子介质来调节神经胶质瘤的血管生成。作为关键的调节分子，细胞内或分泌到肿瘤微环境中的非编码RNA（ncRNA）在神经胶质瘤血管生成中发挥着重要作用。在本综述中，我们简要总结了近期关于ncRNA在肿瘤微环境中的产生、传递和功能的研究，以及ncRNA调控血管生成的分子机制。我们还讨论了基于ncRNA的治疗策略在神经胶质瘤抗血管生成治疗中的应用。
