Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Vascul Pharmacol. 2020 Oct-Nov;133-134:106778. doi: 10.1016/j.vph.2020.106778. Epub 2020 Aug 9.
Angiogenesis has critical roles in numerous physiologic processes during embryonic and adult life such as wound healing and tissue regeneration. However, aberrant angiogenic processes have also been involved in the pathogenesis of several disorders such as cancer and diabetes mellitus. Vascular endothelial growth factor (VEGF) is implicated in the regulation of this process in several physiologic and pathologic conditions. Notably, several non-coding RNAs (ncRNAs) have been shown to influence angiogenesis through modulation of expression of VEGF or other angiogenic factors. In the current review, we summarize the function and characteristics of microRNAs and long non-coding RNAs which regulate angiogenic processes. Understanding the role of these transcripts in the angiogenesis can facilitate design of therapeutic strategies to defeat the pathogenic events during this process especially in the human malignancies. Besides, angiogenesis-related mechanisms can improve tissue regeneration after conditions such as arteriosclerosis, myocardial infarction and limb ischemia. Thus, ncRNA-regulated angiogenesis can be involved in the pathogenesis of several disorders.
血管生成在胚胎期和成年期的许多生理过程中起着关键作用，如伤口愈合和组织再生。然而，异常的血管生成过程也参与了几种疾病的发病机制，如癌症和糖尿病。血管内皮生长因子（VEGF）在几种生理和病理情况下调节这一过程。值得注意的是，几种非编码 RNA（ncRNA）已被证明通过调节 VEGF 或其他血管生成因子的表达来影响血管生成。在本综述中，我们总结了调节血管生成过程的 microRNAs 和长非编码 RNA 的功能和特征。了解这些转录物在血管生成中的作用可以促进设计治疗策略来对抗这一过程中的致病事件，特别是在人类恶性肿瘤中。此外，血管生成相关机制可以改善动脉粥样硬化、心肌梗死和肢体缺血等情况下的组织再生。因此，ncRNA 调节的血管生成可能参与了几种疾病的发病机制。
